Salieva Rana Sherbaevna1,2*, Esenalieva Zhasgul1, Mamyrova Kanykey1, Mamatova Sabira1, Ahzimamtova Rakhima1 and Murzabek K Asel1
1International Medical Faculty, Osh State University, Osh, Kyrgyz Republic 2Osh District Hospital, Osh, Kyrgyz Republic
1International Medical Faculty, Osh State University, Osh, Kyrgyz Republic
2Osh District Hospital, Osh, Kyrgyz Republic
*Corresponding Author: Salieva Rana Sherbaevna, International Medical Faculty, Osh State University, Osh, Kyrgyz Republic.
Received: June 09, 2021; Published: November 30, 2021
Background: The first case of COVID-19 was registered in China in 2019 and speared worldwide, causing considerable challenges in humanity. Since the beginning of the outbreak, COVID-19 is diagnosed by detecting SARS-CoV-2 RNA using real-time reverse-transcriptase polymerase chain reaction (rtRT-PCR). Nowadays, people are traveling with the negative PCR test result. The current study aimed to determine and outline the common clinical symptoms and laboratory features of negative PCR and PCR positive COVID -19 patients test with typical radiological findings.
Methods: This retrospective study was conducted with 188 adult inpatients from Osh City, Kyrgyzstan's regional hospital database. The patients were divided into two subgroups as per their negative and positive RT-PCR report with characteristic radiological signs, and then we compared all characteristic signs among each subgroup. The demographic information, clinical presentations, and laboratory data were collected from the concerned hospitals' electronic medical records. The study excluded admitted patients without radiology confirmed signs of pulmonary infiltrations.
Results: Among the 188 patients, we found 113 negative RT-PCR patients, i.e. about 61.5% of patients, and positive RT-PCR were found among 75 patients (39.8%). Common clinical presentations were different stages of dyspnea, fever, non-productive cough, throat pain, muscle aches, and the same in both groups (Figure 1). The most frequent reported radiological patterns were multifocal bilateral ground-glass patchy opacities recorded size involvement greater than 25% found in almost 174 (92.5%) cases, and unilateral infiltration (particularly right-sided) was found in 14 (7.4%) of cases. The most typical laboratory findings indicate lymphocytopenia, neutrophils, and two-fold and three-fold increased level of fibrinogen A, relatively increased thrombocytes, and prolonged prothrombin time found the same quantities in both groups of patients with COVID -19 with PCR negative and positive cases.
Conclusion: The PCR test is not sensitive for diagnosing and monitoring COVID-19; it would be a better correlation of clinical findings such as new-onset pneumonia-like symptoms and chest radiology patterns with blood coagulogram test. The use of hemostasiogramma can be helpful and relevant for the differential diagnosis between classical-bacterial pneumonia and coronavirus -19 pneumonia.
Keywords: COVID-19; RT-PCR; SARS-CoV-2; Pneumonia; Kyrgyzstan
Citation: Salieva Rana Sherbaevna., et al. “Symptoms Clusters Associated with COVID-19 Infection in Community-Based Populations: A Cross-Sectional Analysis of 188 Cases from Kyrgyzstan". Acta Scientific Clinical Case Reports 2.12 (2021): 56-60.
Copyright: © 2021 Salieva Rana Sherbaevna., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.