Acta Scientific Clinical Case Reports

Case Report Volume 2 Issue 12

Anti-NMDAR Related Autoimmune Encephalitis and Enteritis Associated with Ovarian Dermoid: A Case Report

Neeti A Gupta1*, Sharad M Malvadkar1, Rahul T Chakor2 and Nasreen A Siddiqui3

1Department of Radiology, Sir JJ Hospital and Grant Medical College, India
2Topiwala National Medical College & BYL Nair Charitable Hospital, Mumbai, India
3Saboo Siddique Maternity And General Hospital, Mumbai, India

*Corresponding Author: Neeti A Gupta, Department of Radiology, Sir JJ Hospital and Grant Medical College, India.

Received: October 20, 2021; Published: November 18, 2021


Paraneoplastic limbic encephalitis is a component of the spectrum of Paraneoplastic neurologic disorders (PNDs). It is an immune-mediated neurological condition occurring in the presence of a known remote primary. PNDs have been reported in association with multiple malignancies, the most common one being bronchial carcinoma of lung, typically the small cell variant. Paraneoplastic autoimmune encephalitis (AE) which occurs secondary to the presence of anti-N-methyl D-aspartate receptor (NMDAR) antibodies, has been associated with ovarian teratoma. It has been described as a distinct subcategory of PNDs with a potentially lethal, however, treatment responsive course. Autoimmune enteropathy (AIE) is a rare cause of intractable diarrhea. It is considered as a probable rare complication of autoimmune anti-NMDAR encephalitis.

We present and discuss a unique case of paraneoplastic limbic encephalitis in a young woman with a small ovarian dermoid, who incidentally also presented with autoimmune enteropathy and tested positive for anti-NMDAR antibodies in serum and CSF.

Keywords: NMDA; Autoimmune; Encephalitis; Enteritis; Dermoid


  1. Dalmau J and Rosenfeld MR. “Paraneoplastic syndromes of the CNS”. Lancet Neurology4 (2008): 327-340.
  2. Burton GV., et al. “Paraneoplastic limbic encephalopathy with testicular carcinoma. A reversible neurologic syndrome”. Cancer10 (1988): 2248-2251.
  3. Deshmukh YS., et al. “A case report on paraneoplastic encephalitis associated with astrocytoma–An unknown entity”. Indian Journal of Radiology and Imaging 1 (2016): 140-144.
  4. Shin YW., et al. “Treatment strategies for autoimmune encephalitis”. Therapeutic Advances in Neurological Disorders 11 (2018): 1756285617722347.
  5. Chua KH., et al. “Remove the Ovarian Tumor, Cure the Encephalitis: Anti-NMDAR Encephalitis With Ovarian Teratoma in a Tertiary Hospital in Singapore”. Journal of Medical Cases2 (2017): 52-57.
  6. Gultekin SH., et al. “Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients”. Brain 7 (2000): 1481-1494.
  7. Gentile NM., et al. “Autoimmune enteropathy: a review and update of clinical management”. Current Gastroenterology Reports5 (2012): 380-385.


Citation: Neeti A Gupta., et al. “Anti-NMDAR Related Autoimmune Encephalitis and Enteritis Associated with Ovarian Dermoid: A Case Report". Acta Scientific Clinical Case Reports 2.12 (2021): . Acta Scientific Clinical Case Reports 2.12 (2021): 32-34.


Copyright: © 2021 Neeti A Gupta., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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