Acta Scientific Clinical Case Reports

Case Report Volume 2 Issue 2

Sign and Treatment an Aortic Stenosis: A Review Article

Nanda Rachmad Putra Gofur1*, Aisyah Rachmadani Putri Gofur2, Soesilaningtyas3, Rizki Nur Rachman Putra Gofur4, Mega Kahdina4 and Hernalia Martadila Putri4

1Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Surabaya, Indonesia
2Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
3Department of Dental Nursing, Poltekkes Kemenkes, Surabaya, Indonesia
4Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia

*Corresponding Author: Nanda Rachmad Putra Gofur, Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Surabaya, Indonesia.

Received: January 19, 2021; Published: January 28, 2021



Introduction: Aortic stenosis is the most common heart valve disease in adults and is the third cardiovascular disease after arterial hypertension and coronary artery disease. Based on the Euro Heart Survey on valvular heart disease, aortic stenosis is the single most common primary valve disease (43.1%), and possibly degenerative aortic stenosis in elderly individuals. Stenosis of the aortic valve generally occurs in older adults, where 3-5% of people over the age of 65 have this disease. Aortic stenosis has greater morbidity and mortality than other heart valve diseases. Currently, aortic stenosis is the most common valvular heart disease in the country and its prevalence increases with age. Therefore, with the increase in life expectancy, the population of patients with aortic valve stenosis will increase in number in the future.

Discussion : The prevalence of stenosis of the aortic valve increases with age. Based on the Euro Heart Survey on valvular heart disease, the degenerative process was the dominant etiology of aortic stenosis (81.9%), followed by rheumatic disease (11.2%). Endocarditis accounts for 0.8% of cases of aortic stenosis, congenital aortic stenosis with aortic bicuspid valve occurs in 5.4% of patients, whereas 0.6% is due to other causes. Rare causes of aortic stenosis include metabolic syndrome (Fabry disease), nonspecific infectious disease, erythematous lupus, Pagani's disease, hyperuresemia, changes due to drugs, and post radiation therapy. The three main causes of aortic stenosis include calcification of the trileaflet valve, abnormal congenital valves with calcification (unicuspid or bicuspid), and rheumatic valve disease. Regardless of the etiology, aortic stenosis will cause obstruction in left ventricular emptying leading to concentric hypertrophy where there is an increase in the mass and thickness of the left ventricular wall. This aims to normalize the pressure on the wall during systolic and to keep the left ventricular ejection fraction normal.

Conclusion: After defining symptoms of aortic stenosis, the prognosis without surgical intervention is very poor. There are studies that project that the mean time from symptom onset to death is 2 years for patients with syncope complaints on activity, 3 years for those with symptoms of heart failure, and 5 years for those with angina. More severe symptoms will lead to a worse outcome.

Keywords: Aortic Stenosis; Degenerative; Calcification; Surgery



  1. Eveborn GW., et al. “The evolving epidemiology of valvular aortic stenosis: the Tronso study”. Heart 99 (2013): 396-400.
  2. Otto CM and Prendergast B. “Aortic-valve stenosis - from patients at risk to severe valve obstruction”. The New England Journal of Medicine 371 (2014): 744-756.
  3. Mathieu P and Boulanger MC. “Basic mechanisms of calcific aortic valve disease”. Canadian Journal of Cardiology 30 (2014): 982-993.
  4. Carità P., et al. “Aortic stenosis: insights on pathogenesis and clinical implications”. Journal of Geriatric Cardiology: JGC6 (2016): 489-498.
  5. Carabello BA. “Introduction to aortic stenosis”. Circulation Research 113 (2013): 179-185.
  6. Novo G., et al. “Atherosclerosis, degenerative aortic stenosis and statins”. Current Cancer Drug Targets 12 (2011): 115-121.
  7. Mathieu P., et al. “Molecular biology of calcific aortic valve disease: towards new pharmacological therapies”. Expert Review of Cardiovascular Therapy 2 12 (2014): 851-862.
  8. Bekeredjian R and Grayburn PA. “Valvular Heart Disease: Aortic Regurgitation”. Circulation 112 (2005): 125-134.
  9. Cary T., et al. “Aortic Stenosis: Pathophysiology, Diagnosis, and Medical Management of Nonsurgical Patients”. Critical Care Nurse (2013).
  10. Lugiano CA. “Aortic stenosis”. Journal of the American Academy of Pas1 (2013): 46-47.
  11. Chambers J and Bridgewater B. “Epidemiology of Valvular Heart Disease”. In: Otto CM, Bonow RO, editors. Valvular Heat Disease a companion to Braunwald’s heart Disease. 4th ed. Philadephia: Elsevier Saunder (2014).
  12. Douglas L Mann., et al. “Braunwald’s Heart Disease A Textbook of Cardiovascular Medicine Tenth Edition”. Philadeplhia: Elsevier Saunders (2015): 99-169.
  13. Nishimura RA., et al. “2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines”. Journal of the American College of Cardiology 63 (2014): e57-e185.
  14. Vahanian A., et al. “Guidelines on the management of valvular heart disease (version 2012). Joint task force on the management of valvular heart disease of the European Society of Cardiology (ESC) European Association for Cardio-Thoracic Surgery (EACTS)”. European Heart Journal 33 (2012): 2451-2496.
  15. Grimard BH, Larson JM. “Aortic Stenosis: Diagnosis and Treatment”. American Family Physician (2008).
  16. Akahori Hirokuni Tsujino., et al. “Mechanisms of aortic stenosis”. Journal of Cardiology3 (2017): S0914508717303283.
  17. Iung B., et al. “A Prospective Survey of Patients with Valvular Heart Disease in Europe”. European Heart Journal (2003).
  18. Nishimura RA., et al. “AHA/ACC Guideline for The Management of Patients With Valvular Heart Disease A Report of the American College of Cardiology/American Heart association Task Force on Practice Guidelines”. Journal of the American College of Cardiology 63 (2014): e57-185
  19. Noboru Motomura., et al. “Aortic Valve Surgery”. Intech (2011).
  20. Olizowska M. “Pathogenesis and Pathophysiology of Aortic Valve Stenosis in Adults”. Polskie Archiwum Medycyny Wewnetrznej (2011).
  21. Petr Santavy., et al. “Aortic Valve Stenosis - Current View on Diagnostic and Treatment”. Intech (2011): 35-51.
  22. Sylvia A. Price, Lorraine M. Wilson. Patofisiologi Ed.6. Jakarta : EGC (2003).


Citation: Nanda Rachmad Putra Gofur.., et al. “Sign and Treatment an Aortic Stenosis: A Review Article". Acta Scientific Clinical Case Reports 2.2 (2021): 22-28.


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