Acta Scientific Clinical Case Reports

Case Report Volume 1 Issue 11

Pan-sinusitis in an Immunocompetent Pediatric Patient with a History of Intranasal Cocaine Abuse

Diane Claire Halstead*

Global Infectious Disease Consultants, LLC, USA

*Corresponding Author: Diane Claire Halstead, Global Infectious Disease Consultants, LLC, USA.

Received: October 16, 2020; Published: November 18, 2020



  Pan-sinusitis due to dematiaceous (darkly pigmented) fungi appears to be increasing in frequency. The following report describes an immunocompetent pediatric female with a history of nasal congestion, rhinorrhea, severe headaches, and proptosis. Her social history included cocaine snorting and chronic use of intranasal steroid-containing sprays. A purulent, foul-smelling yellowish-green mucus and right ethmoid sinus tissue were submitted for bacterial and fungal cultures and pathology studies. The stains were positive for black-pigmented, septate hyphae and fungal cultures grew dematiaceous, furry-like colonies. Macroscopic and microscopic appearance of growth was consistent with the mold, Curvularia. Her sinuses contained sheets of eosinophils along with numerous Charcot leyden crystals. These findings along with the isolation and identification of Curvularia, were diagnostic for allergic fungal pan-sinusitis. Fungal sinusitis should be considered in the differential diagnosis of patients presenting with a similar history.

Keywords: Pediatric; Immunocompetent; Pansinusitis; Cocaine-Abuse; Dematiaceous Fungus



  1. Nash D., et al. “Sinusitis”. Pediatric Review 4 (2001): 111-117.
  2. Baptist Health Jacksonville. “Sinusitis”.
  3. Bartynski JM., et al. “Allergic fungal sinusitis secondary to dematiaceous fungi-Curvularia lunata and Alternaria”. Otolaryngology-Head and Neck Surgery 1 (1990): 32-39.
  4. Ebright JR., et al. “Invasive sinusitis and cerebritis due to Curvularia clavate in an immunocompetent adult”. Clinical Infectious Diseases Brief Reports 28 (1999): 687-689.
  5. Zinreich SJ., et al. “Fungal sinusitis; diagnosis with CT and MR imaging”. Radiology 169 (1988): 439-444.
  6. Gonzalez II., et al. “Three new Curvularia species from clinical and environmental sources”. Myco Keys 68 (2020): 1-21.
  7. Guarro J., et al. “Mycotic keratitis due to Curvularia senegalensis and In Vitro antifungal susceptibilities of Curvularia spp”. Journal of Clinical Microbiology 12 (1999): 4170-4173.
  8. Ismail Y., et al. “Invasive sinusitis with intracranial extension caused by Curvularia lunata”. Archives of Internal Medicine 153 (1993): 1604-1606.
  9. Zieske LA., et al. “Dematiaceous fungal sinusitis”. Otolaryngology-Head and Neck Surgery 105 (1991): 567-577.
  10. Washburn RG., et al. “Chronic fungal sinusitis in apparently normal hosts”. Medicine 4 (1998): 231-247.
  11. Killingsworth SM and S J Wetmore. “Curvularia/Drechslera sinusitis”. Laryngoscope 100 (1990): 932-937.
  12. Revankar SG., et al. “Melanized fungi in human disease”. Clinical Microbiology Reviews 4 (2010): 884-928.
  13. Katzenstein AA., et al. “Allergic Aspergillus sinusitis: A newly recognized form of sinusitis”. The Journal of Allergy and Clinical Immunology 72 (1983): 89-93.
  14. Rinaldi MG., et al. “Human Curvularia Report of five cases and review of the literature”. Diagnostic Microbiology and Infectious Disease 5 (1987): 27-39.
  15. Villa PD. “Midfacial complications of prolonged cocaine snort”. Journal of the Canadian Dental Association 63 (1999): 218-223.
  16. DI Cosola., et al. “Cocaine-related syndrome and palatal reconstruction: report of a series of cases”. International Journal of Oral and Maxillofacial Surgery 8 (2007): 721-727.
  17. Graf J. “Rheumatic manifestations of cocaine use”. Current Opinion in Rheumatology1 (2013): 50-55.


Citation: Diane Claire Halstead. “Pan-sinusitis in an Immunocompetent Pediatric Patient with a History of Intranasal Cocaine Abuse". Acta Scientific Clinical Case Reports 1.11 (2020): 03-06.


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