Agilinko Joshua1,2* and Agilinko Bertrand3
1University of Bristol, School of Medicine, Bristol, UK
2Department of Respiratory Medicine, Queen’s Hospital, Burton, UK
3Department of Medicine and Surgery, Sandema District Hospital, Sandema, Ghana
*Corresponding Author: Agilinko Joshua, Department of Respiratory Medicine, University of Bristol, Queen’s Hospital, Burton, UK.
Received: September 18, 2020; Published: September 30, 2020
Introduction: Acute severe asthma presenting in the paediatric population is a medical emergency. The British Thoracic Society (BTS) recommends salbutamol as first line therapy. Intravenous (IV) aminophylline has been shown to be of clinical importance.
Methods: A systematic review of literature was conducted using Cochrane Library, MEDLINE and EMBASE. Using a PICO question, the authors compared clinical outcomes of salbutamol and intravenous aminophylline.
Results/Evidence synthesis: 3 studies were included in the review. They were a Cochrane review of randomised controlled trials (RCTs) and two RCTs. The studies demonstrated that IV aminophylline is as effective as salbutamol in the treatment of children with acute severe asthma in hospital.
Lay Summary/Conclusion: Either IV aminophylline or salbutamol can be used as first line therapy in acute severe asthma in the paediatric population.
Level of Evidence: 1.
Keywords: Salbutamol; Aminophylline; Asthma
Citation: Agilinko Joshua and Agilinko Bertrand. “Comparison of Salbutamol and Intravenous Aminophylline in Acute Severe Asthma in the Paediatric Population". Acta Scientific Clinical Case Reports 1.9 (2020): 36-40.
Copyright: © 2020 Agilinko Joshua and Agilinko Bertrand. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.