Acta Scientific Clinical Case Reports

Case Report Volume 1 Issue 9

Comparison of Salbutamol and Intravenous Aminophylline in Acute Severe Asthma in the Paediatric Population

Agilinko Joshua1,2* and Agilinko Bertrand3

1University of Bristol, School of Medicine, Bristol, UK
2Department of Respiratory Medicine, Queen’s Hospital, Burton, UK
3Department of Medicine and Surgery, Sandema District Hospital, Sandema, Ghana

*Corresponding Author: Agilinko Joshua, Department of Respiratory Medicine, University of Bristol, Queen’s Hospital, Burton, UK.

Received: September 18, 2020; Published: September 30, 2020



Introduction: Acute severe asthma presenting in the paediatric population is a medical emergency. The British Thoracic Society (BTS) recommends salbutamol as first line therapy. Intravenous (IV) aminophylline has been shown to be of clinical importance.

Methods: A systematic review of literature was conducted using Cochrane Library, MEDLINE and EMBASE. Using a PICO question, the authors compared clinical outcomes of salbutamol and intravenous aminophylline.

Results/Evidence synthesis: 3 studies were included in the review. They were a Cochrane review of randomised controlled trials (RCTs) and two RCTs. The studies demonstrated that IV aminophylline is as effective as salbutamol in the treatment of children with acute severe asthma in hospital.

Lay Summary/Conclusion: Either IV aminophylline or salbutamol can be used as first line therapy in acute severe asthma in the paediatric population.

Level of Evidence: 1.

Keywords: Salbutamol; Aminophylline; Asthma



Citation: Agilinko Joshua and Agilinko Bertrand. “Comparison of Salbutamol and Intravenous Aminophylline in Acute Severe Asthma in the Paediatric Population". Acta Scientific Clinical Case Reports 1.9 (2020): 36-40.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

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