Microbial Aspects of Cancer Progression: A Conventional Approach
Ashish Pareek1* and Dhruv Mishra2
1Department of Biotechnology, Stani Memorial PG College, India
2Department of Biotechnology, Dr. B. Lal Institute of Biotechnology, India
*Corresponding Author: Ashish Pareek, Department of Biotechnology, Stani Memorial PG College, India.
June 27, 2022; Published: July 08, 2022
Cancer is defined as the uncontrolled proliferation of cells due to malignancy being caused due to certain factors such as genetic variations, mutations and Chemical factors that contribute to the increment of cancer as a worldwide disease making it one of the prominent disorders of the human body. However, in developed countries, worldwide cancer accounts for 20% of the deaths due to the lack of proper diagnosis or lack of proper treatment. In developing countries like India cancer is increasing at a fast pace most of the cases are arising and reported as lung cancer, liver cancer, and Cervical Cancer to name a few. There is one more aspect of cancer that is one of the most important parts which is the microbiota or microorganisms causing cancer, they play an important role as viruses, bacteria, and other such organisms holds a great potential to cause and generate optimum conditions for cancer. Bacteria can increase the development of cancer by manipulating animal cell signaling pathways, alteration in metabolites, and causing inflammation, however, these microorganisms can cause cancer under certain geographical and environmental conditions. Some of the prominent causatives in different areas of the body are helicobacter pylori for stomach cancer, Papillomavirus for cervical cell carcinoma, Epstein-Barr virus for Burkitt’s lymphoma, and Streptococcus Ovis for Colorectal cancer. In recent trends it is being observed that the microorganisms are responsible for 15-20% increase in lung cancer, carcinoma, and liver cancer, major causative organisms are responsible also included the factors that these organisms are drug-resistant as well. This review aims toward the microbiological aspect of cancer and the analysis of detailed factors responsible for causing cancer progression.
Keywords: Cancer; Polyomavirus; Radiotherapy; Chemotherapy
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