Acta Scientific Anatomy

Research Article Volume 3 Issue 3

A Comprehensive Review of the Roles of Microglia and Potential Therapeutic Approach in Neuroinflammation and Brain Diseases

Emmanson Emmanson Godswill*, Amagula Ikechukwu, Blessing Hajo Isa, Uchechukwu Gift Chinenye, Antonia Bolanle and Eze Constance Nonye

Department of Human Anatomy, Cross River University of Technology, Nigeria

*Corresponding Author: Emmanson Emmanson Godswill, Department of Human Anatomy, Cross River University of Technology, Nigeria.

Received: February 27, 2024; Published: March 08, 2024

Abstract

This review investigates the intricate roles of microglia in neuroinflammation and neurological disorders, aiming to address fundamental research questions regarding their function and dysregulation. With the goal of understanding the nuanced interactions between microglia and the brain in health and disease, this study delves into the impact of aging on microglia function, the mechanisms underlying neurotoxicity in neurodegenerative diseases, and the dynamic responses of microglia to environmental cues. Through a systematic literature search and synthesis of existing knowledge, the review highlights the diverse functions of microglia, including synaptic pruning, inflammation modulation, and neurodegeneration. Additionally, the study discusses the implications of glial-neuronal interactions in propagating neuroinflammation and exacerbating neuronal damage, underscoring the need for targeted therapeutic interventions. By elucidating the complex roles of microglia in neurological disorders, this review provides insights into potential strategies for modulating neuroinflammatory responses and preserving brain health. Further research is warranted to elucidate specific molecular mechanisms and develop precision medicine approaches for effective therapeutic interventions.

Keywords: Microglia; Neuroinflammation; Neurodegenerative Diseases; Aging, Alzheimer's Disease; Synaptic Pruning; Glial-Neuronal Interactions; Reactive Microgliosis; Inflammation; Therapeutic Strategies

References

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Citation

Citation: Emmanson Emmanson Godswill., et al. A Comprehensive Review of the Roles of Microglia and Potential Therapeutic Approach in Neuroinflammation and Brain Diseases".Acta Scientific Anatomy 3.3 (2024): 29-35.

Copyright

Copyright: © 2024 Emmanson Emmanson Godswill., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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