Acta Scientific Anatomy

Research Article Volume 3 Issue 3

A Study on Pathophysiology and Emerging Therapeutic Targets of Neurodegenerative Diseases

Emmanson Emmanson Godswill1*, Eze Constance Nonye2, Amagwula Ikechukwu Otuosorochi3, Anthonia Bolanle Ojomo4, Toluwalope Y Oni5, Abdwahab Abdsalam Babatunde6, Uchechukwu Gift Chinenye7 and Ochai Onyiba Blessing8

1Department of Human Anatomy, Cross River University of Technology, Nigeria
2Department of Public Health, Federal University of Technology, Owerri
3Department of Community Health, Glasgow Caledonian University
4Department of Pharmacy, Universite De Parakou
5Department of Biochemistry, Federal University of Technology, Akure
6Department of Biochemistry, Olabisi Onabanjo University
7Department of Pharmaceutical Sciences, University of Nigeria, Nsukka
8Department of Medical laboratory Science, University of Jos

*Corresponding Author: Emmanson Emmanson Godswill, Department of Human Anatomy, Cross River University of Technology, Nigeria.

Received: February 27, 2024; Published: March 04, 2024


Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), are disorders that affect the structure and function of neurons in the central nervous system, leading to progressive loss of cognitive and motor abilities. Understanding the complex pathophysiology underlying these disorders is crucial for the development of effective therapeutic interventions. In this literature review, we explored recent advancements in elucidating the pathogenesis of neurodegenerative diseases and identify emerging therapeutic targets based on a selection of key review articles, original research papers, and clinical trials. We focused on the role of amyloid-beta (Aβ) and calcium dysregulation in AD, alpha-synuclein (α-syn) and deep brain stimulation in PD, and mutant huntingtin and gene silencing in HD. We also discussed the challenges and opportunities in translating promising preclinical findings into effective treatments, and highlighted the need for a comprehensive understanding of the molecular and cellular mechanisms underlying neurodegeneration, as well as the identification of novel biomarkers and therapeutic targets.

Keywords: Neurodegenerative Diseases; Alzheimer's Disease; Parkinson's Disease; Huntington's Disease; Protein Aggregation; Neuroinflammation; Calcium Dysregulation; Therapeutic Targets; Amyloid-Beta; Alpha-Synuclein; Mutant Huntingtin; Clinical Trials; Biomarkers; Genetics; Environmental Factors; Neuroanatomy; Neurochemistry


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Citation: Emmanson Emmanson Godswill., et al. “A Study on Pathophysiology and Emerging Therapeutic Targets of Neurodegenerative Diseases".Acta Scientific Anatomy 3.3 (2024): 03-11.


Copyright: © 2024 Emmanson Emmanson Godswill., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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