Acta Scientific Clinical Case Reports

Case Report Volume 2 Issue 9

Cutaneous Histoplasmosis in a Renal Allograft Recipient

Jose Perumpillil Paul1*, Babu Francis1, Nimmy Jose2 and Rohitha Mahesh3

1Department of Nephrology, Lisie Hospital, Cochin, Kerala, India
2Department of Pathology, Lisie Hospital, Cochin, Kerala, India
3Department of Microbiology, Lisie Hospital, Cochin, Kerala, India

*Corresponding Author: Jose Perumpillil Paul, Department of Nephrology, Lisie Hospital, Cochin, Kerala, India.

Received: July 26, 2021; Published: August 06, 2021


  Solid transplant organ recipients on potent immunosuppressive medications are at an increased risk of infections by atypical organisms including fungi. Often the presentation of such infections is atypical and requires a high degree of clinical suspicion aided by appropriate diagnostic tests to arrive at a diagnosis. We report a renal transplant recipient who presented with an atypical presentation of Histoplasmosis, ten years after transplantation.

Keywords: Solid Transplant Organ; Transplantation; Histoplasmosis


  1. Deepe GS Jr. “Histoplasma Capsulatum, Mandall, Douglas and Bennett's Principles and Practice of Infectious Diseases (6th Edition) Elsevier Churchill Livingstone 2 (2005): 3012-3021.
  2. Cuellar Rodriguez J., et al. “Histoplasmosis in solid organ transplant recipients: 10-year experience at a large transplant center in an endemic area”. Clinical Infectious Diseases 49 (2009): 710-716.
  3. Davies SF., et al. “Disseminated Histoplasmosis in renal transplant recipients”. The American Journal of Surgery 137 (1979): 686-691.
  4. Miller HE., et al. “Histoplasmosis: cutaneous and mucomembranous lesions, mycologic and pathologic observations”. Archives of Dermatology Syphilology 56 (1947): 715.
  5. Sun NZ., et al. “Cutaneous histoplasmosis in renal transplant recipients. Review Article”. Clinical Transplantation 28 (2014): 1069-1074.
  6. Wong SY and Allen DM. “Transmission of disseminated histoplasmosis via cadaveric renal transplantation: case report”. Clinical Infectious Diseases 14 (1992): 232-234.
  7. Kauffman CA., et al. “Histoplasmosis in Immunosuppressed patients”. The American Journal of Medicine 64 (1978): 923-932.
  8. Goodwin RA Jr., et al. “Disseminated Histoplasmosis: clinic and pathologic correlations”. Medicine 59 (1980): 1-33.
  9. Peddi VR., et al. “Disseminated histoplasmosis in renal allograft recipients”. CLIN Transplant 10 (1996): 160-165.
  10. Motta ACF., et al. “Unusual Orofacial manifestation of histoplasmosis in renal transplant patient”. Mycopathologia 161 (2006): 161-165.
  11. Studdard J., et al. “Cutaneous histoplasmosis”. The American Review of Respiratory Disease 113 (1976): 689.
  12. Pasqualoto AC., et al. “Cryptococcal cellulitis in a renal transplant patient”. Nephrology Dialysis Transplantation 20 (2005): 2007-2008.
  13. Van Grieeken SAH., et al. “Primary cryptococcal cellulitis in a lung transplant patient”. Heart Lung Transplant 26 (2007): 285-289.
  14. Connolly PA., et al. “Detection of histoplasma antigen by a quantitative enzyme immunoassay”. Clinical and Vaccine Immunology 14 (2007): 1587-1591.
  15. Hage CA., et al. “A multicentre evaluation of tests for diagnosis of histoplasmosis”. Clinical Infectious Diseases 53 (2011): 448.
  16. Bialek R., et al. “Evaluation of two nested PCR assays for detection of Histoplasma capsulatum DNA in human tissue”. Journal of Clinical Microbiology 40 (2002): 1644-1647.
  17. McGuinn ML., et al. “Progressive disseminated Histoplasmosis presenting as cellulitis in a renal transplant patient”. Nephrology Dialysis Transplantation 20 (2005): 2007-2008.
  18. Wheat LJ., et al. “Clinical practice guidelines for the management of patients with Histoplasmosis: 2007 update by the Infectious Diseases Society of America”. Clinical Infectious Diseases 45 (2007): 807-825.
  19. Friefeld Iwen PC., et al. “Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant centre”. Transplant Infectious Disease 7 (2005): 109-115.
  20. Restrepo A., et al. “Salvage treatment of histoplasmosis with Posaconazole”. Journal of Infection 54 (2007): 319-327.
  21. Kohler S., et al. “Comparison of the echinocandin caspofungin with Amphotericin B for treatment of histoplasmosis following pulmonary challenge in a murine model”. Antimicrobial Agents and Chemotherapy 44 (2000): 1850-1854.


Citation: Jose Perumpillil Paul., et al. “Cutaneous Histoplasmosis in a Renal Allograft Recipient". Acta Scientific Clinical Case Reports 2.9 (2021): 19-23.


Copyright: © 2021 Jose Perumpillil Paul., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US