Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Review Article Volume 7 Issue 7

Normal Hematopoiesis and Hematologic Malignancies: Role of Wnt/β-catenin and PI3K/AKT Cell Signaling Cascades

Armel Hervé Nwabo Kamdje1*, Richard Tagne Simo2 and Hetvet Paulain Dongmo Fogang1

1Department of Physiological Sciences and Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Garoua, Garoua, Cameroon
2Department of Biomedical Sciences, University of Ngaoundere, Cameroon

*Corresponding Author: Armel Hervé Nwabo Kamdje, Department of Physiological Sciences and Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Garoua, Garoua, Cameroon.

Received: July 28, 2023; Published: August 14, 2023


Wnts are a family of evolutionary-conserved secreted signaling molecules and PI3K-Akt is an intracellular signal transduction. These signaling pathways play significant roles in stromal microenvironment control of the balance between hematopoietic stem cell self-renewal and differentiation. An increasing body of evidence also indicates Wnt and PI3K signaling involvement in the disruption of this balance in hematologic malignancies, where the stromal microenvironment niche favors the infiltration and homing of cancer cells in the bone marrow, as well as leukemia stem cell development and chemoresistance. In the present review, we summarize and discuss the role of the canonical Wnt and PI3K/AKT signaling pathways in normal hematopoiesis and hematologic malignancies, in regards to recent findings on stromal microenvironment involvement in these processes.

 Keywords: Canonical Wnt Signaling Pathway; PI3K-Akt Signaling Pathway; Hematopoiesis; Hematologic Malignancies; Leukemia Stem Cells; Chemoresistance; Cancer


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Citation: Armel Hervé Nwabo Kamdje., et al. “Normal Hematopoiesis and Hematologic Malignancies: Role of Wnt/β-catenin and PI3K/AKT Cell Signaling Cascades" Acta Scientific Cancer Biology 7.7 (2023): 08-19.


Copyright: © 2023 Armel Hervé Nwabo Kamdje., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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