Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Mini Review Volume 4 Issue 11

Early Onset Colorectal Cancer in the United Arab Emirates, Where do we Stand?

Humaid O. Al-Shamsi1-4*, Adhari Abdullah Alzaabi5*, Amr Hassan1,2,4, Ibrahim Abu-Gheida1,2,4 and Sadir Alrawi1,2,4

1Department of Oncology, Burjeel Cancer Institute, Burjel Medical City, Abu Dhabi, United Arab Emirates
2Innovation and Research Center, Burjeel Cancer Institute, Burjel Medical City, Abu Dhabi, United Arab Emirates
3College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
4Emirates Oncology Society, Dubai, United Arab Emirates
5Sultan Qaboos University, Sultanate of Oman

*Corresponding Author: Humaid O. Al-Shamsi, Associate Professor, University of Sharjah, Sharjah, United Arab Emirates.

Received: October 23, 2020; Published: October 28, 2020



  The burden of CRC among young adults has been recognized recently as an area that needs further research. Early onset colorectal cancer (EOCRC) is defined as a colorectal cancer that is diagnosed < 50 years of age. there is no consensus between studies if EOCRC is similar or if it has distinct molecular, clinical and epidemiologic features compared to adult onset CRC. EOCRC is usually characterized by an advanced stage at presentation, frequent high-grade cancers and poor prognosis. In the UAE there is anecdotal evidence that > 41% of UAE colon cancer patients are people younger than 50 years, and > 22% of the colon cancer cases are patients below the age of 40. Initiating screening earlier, at age 45 years, is a “qualified” recommendation from the American Cancer Society, yet there is no international recommendations to start earlier than 45 years of age. In the UAE the screening age has been set to start at the age of 40, largely due to the earlier data that shows that > 41% of UAE colon cancer patients are people younger than 50 years. Currently there are no published data regarding the outcome of early CRC screening in the UAE. Targeted surveillance, prevention, and treatment are needed to reduce the cancer burden in this underserved age group.

Keywords: COVID-19; Oncology; Asymptomatic; Infection Prevention and Control



  1. Sumit Gupta., et al. “International Trends in the Incidence of Cancer Among Adolescents and Young Adults”. JNCI: Journal of the National Cancer Institute (2020).
  2. Fidler MM., et al. “Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study”. Lancet Oncology12 (2007): 1579-1589.
  3. Al-Shamsi HO and Alrawi S. “Breast cancer screening in the United Arab Emirates: is it time to call for a screening at an earlier age?” Journal of Cancer Prevention and Current Research 3 (2018): 123-126.
  4. Radwan H., et al. “The epidemiology of cancer in the United Arab Emirates: A systematic review”. Medicine (Baltimore)50 (2018).
  5. Salim N., et al. “An overview of breast cancer epidemiology, incidence and trends from 2008-2016 in Dubai Hospital, Dubai Health Authority, Hospital-Based Cancer Registry”. Journal of Palliative Care and Medicine6 (2018).
  6. Howlader N., et al. “SEER Cancer Statistics Review, 1975-2016”. National Cancer Institute. Bethesda, MD.
  7. Siegel RL., et al. “Colorectal cancer statistics, 2020”. CA: A Cancer Journal for Clinicians (2020).
  8. Siegel RL., et al. “Colorectal cancer incidence patterns in the United States, 1974-2013”. JNCI: Journal of the National Cancer Institute 8 (2017).
  9. Welch HG and Robertson DJ. “Colorectal cancer on the decline—why screening can’t explain it all”. The New England Journal of Medicine 17 (2016): 1605-1607.
  10. Mauri G., et al. “Early‐onset colorectal cancer in young individuals”. Molecular Oncology2 (2019): 109-131.
  11. Bleyer WA., et al. “Cancer in adolescents and young adults” (2017): 127-128.
  12. Tricoli JV., et al. “Biologic and clinical characteristics of adolescent and young adult cancers: acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma”. Cancer 7 (2016): 1017-1028.
  13. Chen FW., et al. “Advanced-Stage Colorectal Cancer in Persons Younger Than 50 Years Not Associated With Longer Duration of Symptoms or Time to Diagnosis”. Clinical Gastroenterology and Hepatology5 (2017): 728-737.e3.
  14. Meester RG., et al. “Trends in incidence and stage at diagnosis of colorectal cancer in adults aged 40 through 49 years, 1975-2015”. JAMA19 (2019): 1933-1934.
  15. Dozois EJ., et al. “Young-onset colorectal cancer in patients with no known genetic predisposition: can we increase early recognition and improve outcome?”. Medicine 5 (2008): 259.
  16. Willauer AN., et al. “Clinical and molecular characterization of early‐onset colorectal cancer”. Cancer12 (2019): 2002-2010.
  17. Fayadh MH. “Colorectal Cancer in Abu Dhabi, UAE - Initial Data 2014-2016”. Colorectal Cancer 2 (2016): 3.
  18. Makki HF and Salem AS. “Colorectal Cancer in UAE, Implications on the Screening Program 2018”. Open Access Journal of Oncology and Medicine2 (2018).
  19. Lin JS., et al. “Screening for Colorectal Cancer: A Systematic Review for the US Preventive Services Task Force: Evidence Synthesis No. 135”. AHRQ publication 1405203-EF-1. Rockville, MD: Agency for Healthcare Research and Quality (2016).
  20. American Cancer Society. Colorectal Cancer Facts and Figures. 2017‐2019 (2017).
  21. Chyke Doubeni. Screening for colorectal cancer: Strategies in patients at average risk,
  22. Stoffel EM., et al. “Germline genetic features of young individuals with colorectal cancer”. Gastroenterology 4 (2018): 897-905.
  23. Stoffel EM and Murphy CC. “Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults”. Gastroenterology2 (2020): 341-353.
  24. DOH colorectal cancer screening program specifications (2019).
  25. Al Abdouli L., et al. “Colorectal cancer risk awareness and screening uptake among adults in the United Arab Emirates”. Asian Pacific Journal of Cancer Prevention 19 (2018): 2343-2349.




Citation: Humaid O. Al-Shamsi., et al. “Early Onset Colorectal Cancer in the United Arab Emirates, Where do we Stand?". Acta Scientific Medical Sciences 4.11 (2020): 24-27.