Acta Scientific Cancer Biology

Research ArticleVolume 2 Issue 5

Dosimetric Comparison of Dynamic IMRT, Field-in-Field IMRT and 3D-CRT in Left-Sided Breast Cancer after Breast-Conserving Surgery

Didem Karacetin1*, Duygu Baycan2, M Ali Nazli3, D Can Trabulus4, M Emin Gunes 5 and Yücel Barut3

1SBU, Bakirköy Dr Sadi Konuk Research and Training Hospital, Radiation Oncology Department, Istanbul, Turkey
2Istanbul Research and Training Hospital, Radiation Oncology Department, Istanbul, Turkey
3Istanbul Research and Training Hospital, Radiology Department, Istanbul, Turkey
4Istanbul Research and Training Hospital, General Surgery Department, Istanbul, Turkey
5SBU, Bakirköy Dr Sadi Konuk Research and Training Hospital, General Surgery Department, Istanbul, Turkey

*Corresponding Author: Didem Karacetin, Assistant Proffesor, SBU, Bakirköy Dr Sadi Konuk Research and Trainin Hospital, Radiation Oncology Department, Istanbul, Turkey.

Received: February 09, 2018; Published: June 27, 2018

Citation: Didem Karacetin., et al. “Dosimetric Comparison of Dynamic IMRT, Field-in-Field IMRT and 3D-CRT in Left-Sided Breast Cancer after Breast-Conserving Surgery". Acta Scientific Cancer Biology 2.5 (2018).

Abstract

Introduction: The purpose of this study was to compare three different types treatment planing Standard wedged tangential-beam 3D conformal radiotherapy (3D-CRT), field-in-field (FIF) and dynamic Intensıty Modulated radıotherapy (d-IMRT) in early breast cancer patients who have undergone lumpectomy. Our aim was to improve dose-distribution homogeneity in the breast and decrease the dose to organs at risk (OAR), i.e. heart and vessels, ipsilateral lung, and contralateral breast.

Material and Method: 3D-CRT, FIF and d-IMRT treatment plans were carried out for 18 patients with cancer of the left breast. Plans were compared according to cumulative dose-volume histogram (c-DVH) analysis in terms of planned treatment volume (PTV), homogeneity index (HI), and conformity index (CI), as well as dose and volume parameters of OARs.

Results: When the targeted volumes receiving 105% and 110% of the prescribed dose in the PTV were compared, significant decreases were found with the d-IMRT technique. In low dose regions d-IMRT plans were founded significantly higher values in total heart, left lung, ipsilateral breast and cardiac vessels (p < 0.01). Monitor Unit (MU) counts were significantly higher in d-IMRT. Dose homogenity in PTV was determined with homogenıty ındex (HI) and it was founded better with d-IMRT.

Conclusions: d-IMRT enables better dose distribution in the PTV. However, OARs volumes exposed to low doses were increased in d-IMRT. It is important for seconder cancer risk. Especially in patients at high risk of heart disease; in the field of low-dose, dose should be considered in heart.

Keywords: Breast Cancer; Field in Field Dynamic İntensity Modulated Radiotherapy; Volumetric Arc Therapy; 3D Conformal Radiotherapy

Copyright: © 2018 Didem Karacetin ., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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