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Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 10

Evaluation of In-Vitro and In-Vivo Anticoagulant Activity of Orange Peel Extract

Tera Sandhya* and Pasumarthy Sree Mahalakshmi

Department of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam, Tirupathi, India

*Corresponding Author: Tera Sandhya, Department of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam, Tirupathi, India.

Received: September 18, 2020; Published: September 21, 2020

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Abstract

  It is a common and necessary procedure that assist avert loss of life yet from slight damages by means of creating clumps or clots in an effort to discontinue bleeding from an injured or damaged vessel. The results acquired from this exploration advocate that the medicinal plant, Orange peel, possesses the capability to inhibit the aggregation of platelets: The extract of the plant peel inhibited the effect of thrombin on the artificial substrate (i.e. chromogenix), and subsequent too inhibited rat aggregation of platelets provoked with ADP, thrombin, and epinephrine. The anti-aggregation of Platelet effectiveness was seen mostly in the extract of the semi-polar solvent extract highest dose indicating the highest effect. The capability of the extract to inhibit the arachidonic acid provoked aggregation of Platelet signify its potential to be developed into an excellent pharmacological anti-platelet and anti-inflammatory medicament.

Keywords: Anticoagulant Activity; Orange Peel Extract; Platelet Aggregation

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Citation

Citation: Tera Sandhya and Pasumarthy Sree Mahalakshmi. “Evaluation of In-Vitro and In-Vivo Anticoagulant Activity of Orange Peel Extract". Acta Scientific Pharmaceutical Sciences 4.10 (2020): 56-66.



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