Abstract

In the present study, an attempt was made to formulate and evaluate herbal cream of Berberis aristate (B. aristata) for the management of Psoriasis. The study is intended to be carried out because of low cost, lesser or no side effects of herbal formulations and its potent action than the allopathic medication. They therefore provide a viable alternative for psoriasis management. The drug was evaluated on the basis of U.V, FT-IR, and DSC study. The herbal cream formulations were prepared by emulsion based method. The prepared cream was evaluated on the basis of viscosity, spreadability, grittiness, and in-vitro drug release. With altering the ratio of base different release patterns of the drug were observed. With an increase in the base ratio, there was increase in drug release of formulation (F1), while further increase in the base ratio leads to initial burst release but as the time proceeds the release of the drug got decreased due to increase in grittiness and viscosity of the formulation (F2). Also decrease in the base ratio leads to decrease in the drug release of formulation F3. The FT-IR and DSC analysis indicates that there was no interaction between drug and excipients. The in vitro drug release kinetics study depict that drug release mechanism follows Fickian diffusion. The optimized F1 formulation which shows satisfactory in vitro release was tested for anti bacterial and anti fungal property. The zone of inhibition was found to be 24.66 ± 1.14 and 20.45 ± 1.26 for bacteria and fungi respectively at 250 ppm.

Keywords: Berberis aristate ; Herbal Cream; Emulsion Based Method; Antifungal; Antibacterial Activity; Skin Irritancy Test and Release Models

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Citation

Citation: Sanjar Alam., et al. “Development and Evaluation of Herbal Cream of Berberis aristate for its Antibacterial and Antifungal Activity".Acta Scientific Pharmaceutical Sciences 4.8 (2020): 12-19.

Copyright

Copyright: © 2020 Sanjar Alam., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.