Usman M1*, Aliyu AB2, Momoh MA3 and Faruq UZ1
1Department of Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria
2Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
3Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria
*Corresponding Author: Usman M, Department of Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria.
Received: June 05, 2020; Published: June 30, 2020
In this study, antioxidant activities of ethanolic extracts, ethyl acetate, n-butanol and chloroform fraction of Vernonia oocephala were evaluated using DPPH free radical scavenging assay, total phenolic contents, reducing power assay and total antioxidant capacity. The free radical scavenging activity expressed as percentage antioxidant activity was highest in ethyl acetate fraction of (EC50 = 20.0 ± 0.005 µg/ml). The total phenolic content was highest in ethyl acetate fraction (106.0 ± 0.003 mg/g GAE). Also, the ethyl acetate fraction exhibited the highest total antioxidant capacity (100 mg g-1 ascorbic acid equivalent). The chloroform fraction exhibited the highest reducing power at all concentrations. There is no significant difference between the standard and the sample (P ≤ 0.05). The results of this study have shown that Vernonia oocephala contains antioxidant chemical substances and therefore can be considered as a good source of natural antioxidants for medicinal uses.
Keywords: Vernonia amygdalina; Antioxidant Activity; DPPH; Folin-Ciocalteu
Citation: Usman M., et al. “Antioxidant Potential of Vernonia occephala". Acta Scientific Pharmaceutical Sciences 4.7 (2020): 55-60.
Copyright: © 2020 Usman M., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.