Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 5

Development and Validation of New Analytical Methods for the Determination of Ketorolac Tromethamine (A Non-Steroidal Anti-Inflammatory Agent)

Duggirala Sree Harsha, Gunuputi Sushma and Mukthinuthalapati Mathrusri Annapurna*

GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, India

*Corresponding Author: Mukthinuthalapati Mathrusri Annapurna, GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, India.

Received: April 13, 2020; Published: May 04, 2019

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Abstract

  Five new spectrophotometric methods have been established for the determination of Ketorolac tromethamine in pharmaceutical formulations. Ketorolac tromethamine is Non-steroidal anti-inflammatory drug used to treat pain. Ketorolac tromethamine is chemically known as k benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. Ketorolac has shown absorption maxima at 323 nm in all the methods. Reagents used such as phosphate buffers (pH 5.0 and 8.0), acetate buffer (pH 4.7), 0.1N NaOH and borate buffer (pH 9.0). Ketorolac tromethamine obeys Beer-Lambert’s law over the concentration range 5 - 30 μg/ml for all the above mentioned methods and all the methods were validated as per ICH guidelines.

Keywords:Ketorolac Tromethamine; Spectroscopy; Phosphate Buffer; Borate Buffer; Acetate Buffer; Sodium Hydroxide, Validation

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Citation

Citation: Mukthinuthalapati Mathrusri Annapurna., et al. “Development and Validation of New Analytical Methods for the Determination of Ketorolac Tromethamine (A Non-Steroidal Anti-Inflammatory Agent)". Acta Scientific Pharmaceutical Sciences 4.5 (2020): 59-62.




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