Mark Obri1,2*, Arjun Pandya1,2, James Lerakis1,2, Alexander Isla1,2, Michael Rich MD2, Ania Henning MD2
1Northeastern Ohio Medical University, Rootstown, Ohio, USA
2Summa Health System, Akron, Ohio, USA
*Corresponding Author: Juna Musa, Postdoctoral Research Fellow, Department of Surgery, Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Received: April 26, 2020; Published: June 09, 2020
Background: Sweet’s Syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder that presents as a rapid onset of tender, inflammatory lesions, which usually appear on the arms, face, and neck. It is histologically characterized by a neutrophilic infiltrate in the dermis with karyorrhexis and massive papillary dermal edema. Sweet’s is subdivided into three classifications based on etiology: classical, malignancy-associated, and drug-induced.
Case Presentation: We present the case of a 55 year old African American woman with a past medical history of smoldering multiple myeloma and hepatitis C who presented to the emergency department with widespread tender bullous lesions on the extremities, trunk, inguinal area, and vulva, along with accompanying polyarthritis. The patient was treated empirically with intravenous methylprednisolone for suspected autoimmune disease following rule out of infectious etiology and vasculitis. Biopsies of the lesions on subsequent hospitalization demonstrated neutrophilic infiltrate of the dermis, and the patient was diagnosed with Sweet’s Syndrome.
Conclusion: It is unknown whether this patient's Sweet’s Syndrome was secondary to her smoldering multiple myeloma, hepatitis C, or idiopathic. We believe that smoldering multiple myeloma was the likely underlying culprit given the link between blood malignancies and Sweet’s Syndrome, the widespread presentation of the lesions, and similar presentations reported in cases of multiple myeloma. Based on our case study, we recommend patients diagnosed with Sweet’s Syndrome receive appropriate workup for blood malignancies and hepatitis C.
Keywords: Sweet’s Syndrome; Smoldering Multiple Myeloma; Hepatitis C
Citation: Mark Obri., et al. “Recurrent Sweet’s Syndrome in a Case of Smoldering Multiple Myeloma and Chronic Hepatitis C". Acta Scientific Medical Sciences 4.7 (2020): 03-07.
Copyright: © 2020 Mark Obri., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.