Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Review Article Volume 4 Issue 1

Black Cohosh (Actaea racemosa) for the Relief of Menopausal Indications: A Review

Anirban Adhikary1, Kakoli Halder1*, Debmalya Ghosh1, Indranil Chatterjee2 and Suman Kumar Nath2

1B. Pharm, Birbhum Pharmacy School, Birbhum, West Bengal, India
2Assistant Professor, Birbhum Pharmacy School, Birbhum, West Bengal, India

*Corresponding Author: Kakoli Halder, B. Pharm, Birbhum Pharmacy School, Birbhum, West Bengal, India.

Received: September 01, 2020; Published: December 09, 2020

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Abstract

  The motivation behind this article is to survey ongoing information supporting the security and viability of black cohosh items for the relief of menopause-related side effects. Searches of the distributed writing in Napralert, Cochrane Library and PubMed databases were performed from 2003 to 2006. Data from sedate administrative organizations from five distinct nations was gotten to assess wellbeing. While there are a couple of opposing examinations, most of the clinical preliminaries demonstrate that concentrates of black cohosh (Actaea racemosa L.) improve menopause-related indications. Be that as it may, until this point, in any event 50 instances of conceivable hepatotoxicity have been accounted for. Albeit past security surveys propose that black cohosh is very much endured, the expanding quantities of these case reports shows that further preclinical toxicological assessments of black cohosh are desperately required. As of now, it seems reasonable to prompt menopausal ladies with hidden liver infection, immune system maladies or those taking drugs that may affect liver capacity not to utilize items containing dark cohosh.

Keywords: Actaea racemose; Hormone Substitution Treatment (HRT); Hot Glimmers

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References

  1. WHO Annual Report 2001. WHO Publications Office, Geneva, Switzerland (2003).
  2. Houmard BS and Seifer DB. “Predicting the onset of menopause”. In: Menopause, Endocrinology and Management. Seifer DB, Kennard EA (Eds), Humana Press, NJ, USA (1999): 1-20.
  3. Mahady GB. “Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms”. Treatment in Endocrinology3 (2005): 177-184.
  4. World Health Organization Scientific Group: Research on the menopause, WHO Technical Report Ser. 670. World Health Organization, Geneva Switzerland (1981).
  5. Brosage P. “Hormone therapy: the woman’s decision”. Contemporary Nursing and Healthcare S1 (1995): 3.
  6. Grodstein F., et al. “Postmenopausal hormone therapy and mortality”. The New England Journal of Medicine 336 (1997): 1769-1775.
  7. Genazzani AR and Gambacciani M. “Controversial issues in climacteric medicine. cardiovascular disease and hormone replacement therapy”. Climacteric 3 (2000): 233-240.
  8. Burkman RT., et al. “Current perspectives on benefits and risks of hormone replacement therapy”. American Journal of Obstetrics and Gynecology 185 (2001): S13-2S3.
  9. Adams C and Cannell S. “Women’s beliefs about ‘natural’ hormones and natural hormone replacement therapy”. Menopause 6 (2001): 433-440.
  10. Mahady GB., et al. “Rhizoma Cimicifugae Racemosae”. In: WHO Monographs on Selected Medicinal Plants. Volume II. World Health Organization, Geneva, Switzerland (2002).
  11. Mahady GB., et al. “Black coshosh: an alternative therapy for menopause?” Nutrition in Clinical Care 5 (2002): 282-289.
  12. Low Dog T. “Menopause: a review of botanical dietary supplements”. American Journal of Medicine12 S (2005): 98-108.
  13. Kronenberg F and Fugh-Berman A. “Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials”. Annals of Internal Medicine 10 (2002): 805-813.
  14. Geller SE and Studee L. “Botanical and dietary supplements for menopausal symptoms: what works, what does not”. Journal of Women’s Health7 (2005): 634-649.
  15. Frei-Kleiner S., et al. “Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial”. Maturitas4 (2005): 397-404.
  16. Munoz GH and Pluchine S. “Cimicifuga racemosa for the treatment of hot flashes in women surviving breast cancer”. Maturitas 44 (2003): S59-S65.
  17. Nappi RE., et al. “Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol”. Gynecology and Endocrinology1 (2005): 30-35.
  18. Osmers R., et al. “Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms”. Obstetrics and Gynecology 105 (2005): 1074-1083.
  19. Pockaj BA., et al. “Pilot evaluation of black cohosh for the treatment of hot flashes in women”. Cancer Investigation 4 (2004): 515-525.
  20. Uebelhack R., et al. “Black cohosh and St. John's wort for climacteric complaints: a randomized trial”. Obstetrics and Gynecology 107 (2005): 247-255.
  21. Verhoeven MO., et al. “Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebocontrolled, double-blind study”. Menopause4 (2005): 412-420.
  22. Vermes G., et al. “The effects of remifemin on subjective symptoms of menopause”. Advances in Therapy2 (2005): 148-154.
  23. Wuttke W., et al. “The Cimicifuga preparation BNO 1055 vs conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers”. Maturitas 44 (2003): S67-S77.
  24. Jacobson JS., et al. “Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer”. Journal of Clinical Oncology 19 (2001): 2739-2745.
  25. Mahady GB. “Is black cohosh estrogenic?” Nutrition Review 61 (2003): 183-186.
  26. Minciullo PL., et al. “Muscle damage induced by black cohosh (Cimicifuga racemosa)”. Phytomedicine 13 (2006): 115-118.
  27. Whiting PW., et al. “Black cohosh and other herbal remedies associated with acute hepatitis”. Medical Journal of Australia 177 (2002): 440-443.
  28. Lontos S., et al. “Acute liver failure associated with the use of herbal preparations containing black cohosh”. Medical Journal of Australia 179 (2003): 390-391.
  29. Cohen SM., et al. “Autoimmune hepatitis associated with the use of black cohosh: a case study”. Menopause 11 (2004): 575-577.
  30. Thomsen M., et al. “Acute liver failure associated with the use of herbal preparations containing black cohosh”. Medical Journal of Australia 180 (2004): 598-600.
  31. Levitsky J., et al. “Fulminant liver failure associated with the use of black cohosh”. Digestive Diseases and Sciences 3 (2005): 538-539.
  32. Manns MP and Obermayer-Straub P. “Cytochromes P450 and uridine triphospateglucuronosyltransferases: model autoantigens to study drug-induced, virus-induced and autoimmune liver disease”. Hepatology 26 (1997): 1054-1066.
  33. Beaune PH., et al. “Autoantibodies against cytochromes P450: role in human diseases”. Advances in Pharmacology 30 (1994): 199-245.
  34. Australian Therapeutic Goods Administration.
  35. Manns MP and Obermayer-Straub P. “Basic Mechanisms in Autoimmune Hepatitis”. The Hepatitis Information Network (2000).
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Citation

Citation: Kakoli Halder., et al. “Black Cohosh (Actaea racemosa) for the Relief of Menopausal Indications: A Review". Acta Scientific Microbiology 4.1 (2021): 60-70.




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