Abstract

   The substantia (“black substance” in Latin) is a long nucleus located in the midbrain but considered functionally a part of the basal ganglia because of its reciprocal connections with other brainstem nucleic. Degeneration of the pars compacta of the substantia nigra result in reduction of the availability of the neurotransmitter dopamine. This lack of dopaminergic innervation to the stratum results in disorders associated with hypokinesia or reduced motor movement. However, Parkinson disease is a result of reduced functioning substantia nigra. A few studies have shown that progenitor cells present in different areas of the adult central nervous system (CNS) but specificity (i.e. SNc) whether such cells reside in the adult SNc and whether they have the potential to replace degenerating neurons effects is unknown. The purpose was to investigate a population of actively dividing progenitor cells in the adult SN, after removal from the SN, these progenitor cells immediately have the potential to differentiate into neurons. Transplantation of freshly isolated SN progenitor cells into the adult hippocampus showed that these cells also have a neuronal potential under in vivo conditions. These results suggest that progenitor cells reside in the adult SN and can give rise to new neurons when exposed to appropriate environmental signals.

Keywords: Parkinson's Disease, Neural Progenitor Cells, Cell Replacement, Gliogenesis, Transplantation, Substantia Nigra

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Citation

Citation: Opeyemi Oluwasanmi Adeloye., et al. “Experimental Evidence for Neural Progenitor Cells in Adult Substantia Nigra". Acta Scientific Microbiology 3.7 (2020): 89-97.

Copyright

Copyright: © 2020 Opeyemi Oluwasanmi Adeloye., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.