Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Study Volume 3 Issue 12

Comorbid Risk Factors for an In-Hospital Fatal Outcome of Patients Hospitalized for Covid -19: A Case-control Study

Niculae Ion Nedelcu1, Magdalena George2 and David H Van Thiel2*

1Infectious and Tropical Diseases Hospital “Dr Victor Babes”, Bucharest, Romania
2Advanced Liver and Gastrointestinal Disease Center, Berwyn, USA

*Corresponding Author: David H Van Thiel, Advanced Liver and Gastrointestinal Disease Center, Berwyn, USA.

Received: November 02, 2020; Published: November 27, 2020

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Abstract

  Between 13 March - 31 July 2020, 2,529 Covid-19 cases were discharged from the Victor Babes 490 bed hospital recognized by the government as the primary Covid-19 hospital in the capital, Bucharest. Eighty six of these 2,529 patients died in hospital for a case fatality rate (CFR) of 3.4 % (95% CI: 2.8 % - 4.2 %). The CFR for males was 4.7 % (54/1127) while in women it was 2.4 % (33/1402). The difference between these two rates is statistically significant [(Relative Risk (RR): 2.04; 95%CI: 1.33 - 3.12; p: 0.00083)]. Among the 86 who died, 11 (12.8%) were previously healthy (no reported under lying medical condition), 77 (87.2%) had at least one under lying medical condition, and 47 (54.7%) had two or more under lying medical conditions. The prevalence of each of the individual under lying medical conditions in these 86 patients was as follows: hypertension (68.6 %), diabetes mellitus (40.7%), obesity (33.7%), chronic kidney disease (27.9 %), and COPD (7.0 %). A 1:1 case control study was conducted after matching each case with one control of the same gender and age selected at random from the survivors list. Significant odds for death were identified for the presence of at least 2 under lying medical condition (OR:23.00; 95% CI (4.29 - 478.82);p: 0.0000), ), chronic kidney disease (OR: 9.00; 95% CI(2.41 - 57.41); p: 0.0008), and obesity (Odds Ratio (OR): 6.75; 95%CI (2.53 - 22.59); p: 0.0001). These data suggest that individuals with 2 or more under lying disease processes, and either chronic renal disease or obesity should be included in the list of individuals recommended for priority vaccination with a COVID-19 vaccine to reduce the likelihood of death should they become infected with COVID-19.

Keywords: COVID - 19; Hospital Cases; Fatality Rates; Case-control Study

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Citation

Citation: David H Van Thiel., et al. “Comorbid Risk Factors for an In-Hospital Fatal Outcome of Patients Hospitalized for Covid -19: A Case-control Study". Acta Scientific Gastrointestinal Disorders 3.12 (2020): 24-27.




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