Basel Mofti1*, Moataz ElShehaby1, Mona A Montasser2 and David Bearn3
1Postgraduate Student, Orthodontics, School of Dentistry, University of
Dundee, Dundee, Scotland, UK
2Professor, Orthodontic Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
3Professor of Orthodontics, School of Dentistry, University of Dundee, Dundee, Scotland, UK
*Corresponding Author: Basel Mofti, Postgraduate Student, Orthodontics, School of Dentistry, University of Dundee, Dundee, Scotland, UK.
Received: July 14, 2020; Published: August 27, 2020
Introduction: The objective of this systematic review and meta-analysis was to assess the effectiveness of various pharmacological interventions on pain experienced by patients undergoing orthodontic therapy.
Methods: PubMed, MEDLINE, Web of Science, and the Cochrane Library databases were searched to February 22, 2020 to identify relevant randomized controlled trials (RCTs) evaluating the effectiveness of any pharmacological interventions for pain relief following orthodontic activation. The Cochrane Collaboration tool for risk of bias evaluation was used. Meta-analysis was carried out using RevMan software with a random-effects' model applied.
Results: Seventeen RCTs were identified, but only ten RCTs with a total of 899 participants were included in the meta-analysis. Meta-analysis showed both ibuprofen and acetaminophen significantly reduced orthodontic pain at 2, 6, and 24 hours when compared to a placebo (P < 0.05). Acetaminophen was further found to reduce pain at 2 and 3 days when compared to a placebo (P < 0.05). Ibuprofen was found to reduce orthodontic pain more at 2 hours (P = 0.01) when compared to acetaminophen.
Conclusions: Both ibuprofen and acetaminophen are equally effective in reducing orthodontic pain at all time points within the first 24 hours. Further high quality research is required to improve the reliability of the evidence.
Keywords: Orthodontic Pain; Pharmacology; Analgesics; NSAID; Systematic Review
Citation: Basel Mofti., et al. “Pharmacological Management of Orthodontic Pain: A Systematic Review and Meta-Analysis”. Acta Scientific Dental Sciences 4.9 (2020): 125-135.
Copyright: © 2020 Basel Mofti., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.