Prerana G1, Aishwarya PR Kumar1 and Gaurav2*
1House Surgeons, NSVK Sri Venkateshwara Dental College and Hospital, Bangalore, Karnataka, India
2Consultant Oral Physician and Maxillofacial Radiologist, Assistant Professor, Department of Oral Medicine and Maxillofacial Radiology, NSVK Sri Venkateshwara Dental College and Hospital, Bangalore, Karnataka, India
*Corresponding Author: Gaurav, Consultant Oral Physician and Maxillofacial Radiologist, Assistant Professor, Department of Oral Medicine and Maxillofacial Radiology, NSVK Sri Venkateshwara Dental College and Hospital, Bangalore, Karnataka, India.
Received: February 29, 2020; Published: March 18, 2020
Background: Hachimoji is a double DNA helix that has an additional 4 nucleotide bases. In normal RNA and DNA, combination of four base pairs enables the storage and transmission of genetic information. The 4 new letters P, B, Z and S approximated the structures and functionally of regular DNA. This is of significance because DNA has always been thought to be unique. DNA is the only materials for which we have the ability to design sequences that have predictable stability, this new four letters satisfy every aspect of this predictable stability as well.
Aim of The Study: To evaluate and emphasize the sensitivity and specificity of Hachimoji DNA in oral therapeutics.
Research Question: Is Hachimoji actually significant enough in detecting and treating specific oral diseases and lesions.
Materials and Methods: With the Medline database taken as a source for authenticated scientific research data, articles were selected having undergone randomized control trial. Out of these, articles (studies) were chosen which met the criterion for systematic review.
Results and Conclusion: We can interpret that Hachimoji DNA comes up with numerous advantages. To name a few, better understanding of its complex structure. Enhanced understanding of different base pairs with its modified properties. Minimising the complexity of nano structures. Synthesis of protein from unusual amino acid. The complexity of DNA and the nucleic acid which once seemed daunted have now been discerned. Thereby, not only modifying and improving the cellular galaxy at a molecular level but also enhancing the approach towards various disease therapeutics which have been so far a challenge to medical and dental science.
Keywords: Advanced Molecular Biology; Oral Medicine Rejuvenated; DNA; RNA
Citation: Gaurav., et al. "Advanced Molecular Biology Concepts: Oral Medicine Rejuvenated - A Systematic Review”. Acta Scientific Dental Sciences 4.4 (2020): 65-68.
Copyright: © 2020 Gaurav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.