Acta Scientific Dental Sciences (ISSN: 2581-4893)

Research Article Volume 4 Issue 3

Potential Use of Adipose-Derived Mesenchymal Stromal Cells and Bone Graft for Dental Implant: A Systematic Review

Wesley Antonio Galhardo Fornazari1 and Idiberto José Zotarelli Filho2/*

1Fornazari Odontology, Street Prudente de Moraes, Downtown, Novo Horizonte/SP, Brazil
2Zotarelli-Filho Scientific Work, São José do Rio Preto/SP, Brazil

*Corresponding Author: Idiberto José Zotarelli Filho, Zotarelli-Filho Scientific Work, São José do Rio Preto/SP, Brazil.

Received: December 11, 2019; Published: February 21, 2020

×

Abstract

Introduction: Over the past 30 years, the number of dental implant procedures has increased worldwide, reaching about one million dental implants per year. In Brazil, in recent decades, there has been a very rapid evolution in implant dentistry with high success rates.

Objective: It was performed a systematic review of the main findings and potential use of adipose-derived stem cell and bone graft for a dental implant. Methods: A total of 55 clinical studies and reviews that were submitted for eligibility analysis were checked, and after that, 38 studies were selected, following the rules of systematic review-PRISMA. The search strategy was performed in PubMed, Embase, Ovid and Cochrane Library, Web of Science, ScienceDirect Journals (Elsevier), Scopus (Elsevier), OneFile (Gale).

Major Findings and Conclusion: Tissue engineering is a tool that allows by means of a suitable biological niche for any construction and regeneration of tissues and organs. Another advantage is minimally invasive surgery or allows the use of surgical techniques that cause less risk to the patient. This condition is maintained because the cells involved in the biological niche secret growth factors for cell proliferation and differentiation and supramolecular structures that ensure the functional organization of tissue generated by means of stereochemistry and its systemic integration ADSCs can potentiate osteogenesis and reduce the possibility of developing bone necrosis. Moreover, the ADSC, when cultured in the presence of bone, releases cytokines osteopoiesis undergo a process that involves the proliferation and maturation of primitive precursor cells to the formation of functional osteoblasts and bone cells originated ADSC this phenomenon is committed osteoprogenitor cells and pre-osteoblasts osteoblasts and osteocytes. Therefore, the lack of bone in the alveolar ridges has been a major problem in functional aesthetic recovery in patients who have suffered dentoalveolar trauma, traumatic tooth extractions, congenitally missing teeth, maxillary and mandibular pathologies. For the filling of large bone defects, the development of bone regeneration improves epithelial barriers to bone graft, favoring dental implantation.

Keywords: Adipose-derived stem cell. Stromal vascular fraction. Platelet-rich plasma. Bone loss. Dental implant.

×

References

  1. Zhou Z., et al. “Two-stage closed sinus lift for severe bone deficiency in the posterior maxilla improves long-term clinical outcomes”. Nan Fang Yi Ke Da Xue Xue Bao 39.6 (2019): 731-735.
  2. IBGE- Instituto Brasileiro de Geografia e Estatística (2019).
  3. Abdel-kader MA., et al. “Oral rehabilitation of a case with regional odontodysplasia using a regenerative approach-A case report and a review of literature”. Special Care in Dentistry 39.3 (2019): 330-339. 
  4. Momen-Heravi F., et al. “Acellular Dermal Matrix as a Barrier for Guided Bone Regeneration of Dehiscence Defects Around Dental Implants: A Clinical and Histological Report”. Implant Dentistry 27.4 (2018): 521-524. 
  5. Moreira AC., et al. “Application of Bio-Oss in tissue regenerative treatment prior to implant installation: literature review”. Brazilian Dental Science 22.2 (2019).
  6. Starch-Jensen T., et al. “A systematic review and meta-analysis of long-term studies (five or more years) assessing maxillary sinus floor augmentation”. International Journal of Oral and Maxillofacial Surgery 47.1 (2018): 103-116. 
  7. Wu IH., et al. “Retrospective Analysis of the Outcome of Ridge Preservation with Anorganic Bovine Bone Mineral: Marginal Bone Level at Implants Placed Following Healing of Grafted Extraction Sockets”. International Journal of Periodontics and Restorative Dentistry 39.1 (2019): 131-140. 
  8. Toplu G., et al. “Adipose Tissue Derived Stromal Vascular Fraction Increases Osteogenesis in an Experimental Design Zygomatic Bone Defect Model”. Journal of Craniofacial Surgery 28.8 (2017): 2179-2182. 
  9. Strauss FJ., et al. “The use of platelet-rich fibrin to enhance the outcomes of implant therapy: A systematic review”. Clinical Oral Implants Research 18 (2018): 6-19. 
  10. Zuk PA., et al. “Multilineage cells from human adipose tissue: implications for cell-based therapies”. Tissue Engineering 7.2 (2001): 211-228.
  11. Pye AD., et al. “A review of dental implants and infection”. Journal of Hospital Infection 72 (2009): 104-110.
  12. Branemark PI., et al. “Osseointegrated implants in the treatment of edentulous jaw. Experience from a 10-year period”. Scandinavian Journal of Plastic and Reconstructive Surgery 16 (1977): 1-192.
  13. Bugarin Júnior JG and GarrafaII V. “Bioethics and biosafety: the use of biomaterials in dental practice”. Revista de Saúde Pública 41.2 (2007):223-228.
  14. Saghiri MA., et al. “The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis”. Med Oral Patol Oral Cir Bucal (2016).
  15. Aubin JE and Liu F. “The osteoblast lineage”. In: Bilizekian, J., Raisz, L., and Rodan, G., editors. Principles of Bone Biology. San Diego, CA: Academic Press (1996): 39-50.
  16. Chan YL and King NM. “Use of focused íon bean milling for investigating the mechanical properties of biological tissues: A study of human primary molars”. Journal of the Mechanical Behavior of Biomedical Materials 2.4 (2009): 375-383.
  17. Gimble JM., et al. “Adipose-Derived Stem Cells for Regenerative Medicine”. Circulation Research 100 (2013): 1249-1260.
  18. Hallman M., et al. “A clinical histologic study of bovine hydroxyapatite in combination with autogenous bone and fibrin glue for maxillary sinus floor augmentation. Results after 6 to 8 months of healing”. Clinical Oral Implants Research 12.2 (2001): 135-143.
  19. Hing KA. “Bone repair in the twenty-first century: biology, chemistry or engineering?” Philosophical Transactions of the Royal Society B: Biological Sciences 362.1825 (2004): 2821-2850.
  20. Langer R and Vacanti JP. “Tissue Engineering”. Science 260 (1993): 920-926.
  21. Lima AF Martorelli. “Enxertos ósseos: características de alguns materiais”. Associação Brasileira de Ouvidores / Ombudsman - ABO Nacional 16.3 (2008).
  22. Liu Y., et al. “Hyaluronic acid-gelatin fibrous scaffold produced by electrospinning of their aqueous solution for tissue engineering applications. In Advances in Material Design for Regenerative Medicine”. Drug Delivery and Targeting/ Imaging 1140 (2010): 131-136.
  23. Locke M., et al. “Human adipose-derived stem cells: isolation, characterization and applications in surgery”. ANZ Journal of Surgery 79 (2009): 235-244.
  24. Mesimäki K., et al. “Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells”. International Journal of Oral and Maxillofacial Surgery 38 (2009): 201-209.
  25. Planat Bernard V., et al. “Plasticity of human adipose lineage cells towards endothelial cells: physiological and therapeutic perspectives”. Circulation 109 (2004): 656 -63.
  26. Vacanti JP and Langer R. “Tissue engineering: The design and fabrication of living replacement devices for surgical reconstruction and transplantation”. Lancet 354 (1999): 32-34.
  27. Valentini P and Abensur D. “Maxillary sinus floor elevation for implant placement with demineralized freeze-dried bone and bovine bone (Bio-Oss®): a clinical study of 20 patients”. International Journal of Periodontics and Restorative Dentistry 17.3 (1997): 232- 241.
  28. Zotarelli Filho IJ., et al. “Chitosan-collagen scaffolds can regulate the biological activities of adipose mesenchymal stem cells for tissue engineering”. Journal of Regenerative Medicine and Tissue Engineering 2 (2013): 12. 
  29. Simonpieri A., et al. “Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience”. Implant Dentistry 20.1 (2011): 2-12.
  30. Anitua E. “Enhancement of Osseointegration By Generating a Dynamic Implant Surface”. Journal of Oral Implantology 32 (2006): 72-76.
  31. Tejero R., et al. “Toward the biomimetic implant surface: Biopolymers on titanium-based implants for bone regeneration”. Journal of Progress in Polimeral Science 39 (2014): 1406-1447.
  32. Paolantonio M., et al. “Autogenous Periosteal Barrier Membranes and Bone Grafts in the Treatment of Periodontal Intrabony Defects of Single-Rooted Teeth: A 12-Month Reentry Randomized Controlled”. Clinical Trial Journal of Periodontology 81.11 (2010):1587-1595.
  33. Zhang Y., et al. “Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study”. Journal of Cranio-Maxillo-Facial Surgery 40 (2012): 321-328.
  34. Tatullo M., et al. “Platelet Rich Fibrin (PRF) in Reconstructive Surgery of Atrophied Maxillary Bones: Clinical and Histological Evaluations”. International Journal of Medical Sciences 9.10 (2012): 872-880. 
  35. Angelo T., et al. “Biomechanical Stability of Dental Implants in Augmented Maxillary Sites: Results of a Randomized Clinical Study with Four Different Biomaterials and PRF and a Biological View on Guided Bone Regeneration”. Hindawi Publishing Corporation BioMed Research International (2015).
  36. Chen Y., et al. “Inlay osteotome sinus floor elevation with concentrated growth factor application and simultaneous short implant placement in severely atrophic maxilla”. Scientific Reports 6 (2016): 27348.
  37. Kumar NK., et al. “Comparative Study of Alveolar Bone Height and Implant Survival Rate Between Autogenous Bone Mixed with Platelet Rich Plasma Versus Venous Blood for Maxillary Sinus Lift Augmentation Procedure”. Journal of Oral and Maxillofacial Surgery 14.2 (2015): 417-422.
  38. You JS., et al. “Effects of Platelet-Derived Material (Platelet-Rich Fibrin) on Bone Regeneration”. Implant Dentistry (2019).
×

Citation

Citation: Wesley Antonio Galhardo Fornazari and Idiberto José Zotarelli Filho. “Potential Use of Adipose-Derived Mesenchymal Stromal Cells and Bone Graft for Dental Implant: A Systematic Review”. Acta Scientific Dental Sciences 4.3 (2020): 59-66.



Member In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is November 10, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US