Omar Chamdine1*, Marwah Abdulkader2, Wisam Al-Issawi3,4, Shaymaa Al-Umran3, Youssef Housaawi5 and Mahmoud Taha3
1Department of Pediatric Hematology Oncology and Stem Cell Transplantation, King Fahad Specialist Hospital, Dammam, Saudi Arabia
2Department of Pathology, King Fahad Specialist Hospital, Dammam, Saudi Arabia
3Department of Neurosurgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia
4Department of Neurosurgery, Imam Abdulrahman bin Faisal University, Saudi Arabia
5Department of Genetics, King Fahad Specialist Hospital, Dammam, Saudi Arabia
*Corresponding Author: Omar Chamdine, Department of Pediatric Hematology Oncology and Stem Cell Transplantation, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Received: October 30, 2020; Published: November 30, 2020
Synchronous and metachronous brain tumors are rare in children. In this report, we present 2 unique cases of synchronous brain tumors and we elaborate on their presentation, diagnosis, approach to management and outcome. The first case is a unique report in the literature describing for the first time a combination of a supratentorial RELA fusion-positive anaplastic ependymoma and a low grade glioma in a child occurring synchronously. The second case describes malignant transformation in one of two low grade gliomas present in the same patient while the other tumor remained low grade. A tailored approach to diagnosis should be taken when dealing with patients presetting with more than one tumor. Histopathologic confirmation of all tumors is recommended in order to personalize therapy.
Keywords: Brain Tumor; Childhood; Ependymoma; Glioma; Metachronous; Synchronous
Citation: Omar Chamdine., et al. “Synchronous Primary Brain Tumors in the Pediatric Age Group. Report of Two Cases and Review of the Literature”. Acta Scientific Cancer Biology 4.12 (2020): 14-19.
Copyright: © 2020 Omar Chamdine., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.