Professor, Department of Pathology, JSS Medical College, Mysore, Karnataka, India
*Corresponding Author: Nandini NM, Professor, Department of Pathology, JSS Medical College, Mysore, Karnataka, India.
Received: April 22, 2020; Published: May 27, 2020
Cancer has been the major cause of morbidity and mortality all over the world. Even though cancer therapy has new ways of
treatment by chemotherapy and radiotherapy, resistance to treatment has become the major cause for mortality of patients. It has
lead to decrease in lifespan of patients even after treatment.
The present review deals with Stem cells (SC), Cancer stem cells (CSC),Epithelial Mesenchymal Transition (EMT)and various aspects of cells leading to drug resistance. The characteristics of CSC like Dormancy, surrounding aspects of tumor like Hypoxia, Tumor microenvironment and Cancer Nische act on the tumor cells in various ways leading to Drug resistance.
Understanding of these various aspects helps in dealing with cancer drug resistance, its effects and various ways to improve tumor response and treatment.
Keywords: Cancer Stem Cell;Epithelial Mesenchymal Transition; Tumor Microenvironment; Drug Resistance
Citation: Nandini NM. “Cancer Stem Cells and Drug Resistance”.Acta Scientific Cancer Biology 4.6 (2020): 12-18.
Copyright: © 2020 Nandini NM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.