Leslie C Costello* and Renty B Franklin
Department of Oncology and the Greenebaum Comprehensive Cancer Center, The University of Maryland School of Dentistry, Baltimore, Maryland, USA
*Corresponding Author: Leslie C Costello, Department of Oncology and Diagnostic Sciences, The University of Maryland, Baltimore, Maryland, USA.
Received: March 03, 2020; Published: April 27, 2020
Evidence is evolving that support the relationship that all carcinomas exhibit the following important relationships: The malignant cells exhibit a significant decreased zinc compared to the normal cells. The higher zinc levels that exist in the normal cells are cytotoxic in the malignant cells. The decrease in zinc is due to the down regulation of the ZIP-family zinc uptake transporter. These cells are as “ZIP-deficient/decreased zinc” malignancies. This provides a target for a chemotherapy that can restore the high zinc levels that will manifest cytotoxic effects in the malignant cells. In order to achieve this, a vehicle that facilitates the uptake and accumulation of zinc in the ZIP-deficient cells is required. The zinc ionophore, clioquinol, exhibits the properties that will provide these requirements. This is demonstrated by the treatment of a patient with 3% Clioquinol Cream, which successfully suppressed the progression of androgen-dependent prostate cancer. This treatment should also be efficacious for pancreatic cancer, liver cancer, breast cancer, thyroid cancer, kidney cancer, stomach cancer, gall bladder cancer, and lung cancer; which are carcinomas that exhibit decreased zinc. Thus, it is appropriate to describe that “Zinc is the wonder drug for the treatment of carcinomas”.
Keywords: Zinc; Carcinomas; Clioquinol; Treatment
Citation: Leslie C Costello and Renty B Franklin. “Zinc: The Wonder Drug for the Treatment of Carcinomas”.Acta Scientific Cancer Biology 4.5 (2020): 33-39.
Copyright: © 2020 Leslie C Costello and Renty B Franklin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.