Sheik Sardar Pasha is an experienced and translational neuroscientist with advanced cell and molecular biology expertise in ophthalmology and neurodegenerative diseases, identified and characterized of 4 gene mutations associated with blinding diseases. After his master’s degree in engineering from India, He moved to Germany for his doctorate through Prestigious DAAD Ph.D. fellowship to pursue his research in Retinal Regeneration in Mammals. His major Ph.D. accomplishment was, He successfully overcame the major roadblocks for retinal regeneration by reprogramming via genetic manipulations and found the epigenetic cell signaling mechanism involved in glia-derived neuronal regeneration in the retina which leads to several well cited papers. After his Ph.D, He moved to post-doctoral studies to Indiana University School of Medicine, Indianapolis to study small compound inhibition for ocular angiogenesis using a forward genetics approach. He developed a novel method and finds a target of the small compound for the treatment of Ocular Neovascularization. His work leads to 5 highly cited papers with1 patent and nurtured 4.5 million US$ funding. Then, He recruited as a Senior Research Scientist at NEI, NIH and UC Davis, Currently, He is working on the disease mechanism and gene therapy for X-linked Retinoschisis (XLRS) which is an inherited retinal disease causing vision loss due to splitting of the layers of the retina.
Retinal Diseases, Cell and Gene therapy, Retinal Regeneration, Stem cell biology, Vascular Biology, Ocular Biology, Neurodegeneration, Neuron-glia interactions, Drug development and Delivery