Dr. V.L.Sirisha did her PhD in Genetics from Osmania University, Hyderabad in the year 2010. During her PhD she could standardize an efficient regeneration protocol for selected varieties of Subabul (Leuceana leucocephala). She developed transgenic tobacco plants with reduced lignin content by antisense technology. She also isolated full length CAD gene promoter by genome walking approach and functionally validated it for tissue specific gene expression. She did her postdoctoral training at the Indian institute of technology, Bombay under the mentorship of Dr. Pramod Wangikar. Dr. Sirisha later joined UM DAE CBS as a Research Associate in the year 2012, got promoted to visiting scientist in 2014 and subsequently was promoted to Assistant Professor in January 2016. Dr. Sirisha stood University second in her post-graduation and ranked first in her under graduation and was awarded gold medal for the same. She has guided multiple projects of BSc and MSc students. Her present research area mainly focuses on understanding and development of medicinally important bioactive compounds from plants and microorganism such as algae. The long term goal is to elucidate the biosynthetic mechanistic pathways of these therapeutically useful compounds and improve their production by metabolic engineering.
Dr. V.L.Sirisha current research interest focuses on identification and characterization of medicinally important bioactive compounds from plants and microorganisms, understanding their coordination with stress response programs and elucidating the regulation of metabolic pathways. We use varied integrated approaches that include plant biology, metabolomics, functional genomics and biochemistry in order to understand and elucidate the metabolic pathway regulators of plant and algal primary and secondary metabolism. We try to decipher the biosynthetic mechanistic pathways of these therapeutically useful compounds and improve their production by metabolic engineering. Earlier I have worked on understanding the abiotic stress induced cell death pathways in unicellular chlorophyte Chlamydomonas reinhardtii. During my PhD I have successfully isolated a crucial enzyme (Cinnamyl alcohol dehydrogenase) of lignin biosynthetic pathway, its associated gene specific promoter and down regulated lignin content in transgenic plants. Areas of Specialization: Plant Stress Physiology; Metabolism and Molecular Biology.