Presently Dr. Maruti Jayram Dhanavade working as Assistant Professor at the Department of Microbiology, Shivaji University Kolhapur, Maharashtra, India. He has completed his Ph.D. in Microbiology on march 2016 at the Department of Microbiology Shivaji University Kolhapur, Maharashtra, India. Topic of his PhD was entitled “Studies on amyloid beta peptide degradation using microbial enzymes”. The Aβ peptides forming Aβ plaques are primary cause of Alzheimer’s disease. In recent years detailed understanding of proteolysis of Aβ peptides evaluated as potential therapeutic targets for Alzheimer’s disease. In this respect, they have focused on proteolytic mechanism of aminopeptidase from Streptomyces griseus KK565 (SGAK) in Aβ peptide degradation. The computational studies are helpful to understand the ligand-protein and protein-protein interaction and their different conformations. The Molecular docking and Molecular Dynamic simulations techniques are used to explore the binding mode of Aβ peptide to determine amino acid residues involved its recognition. This obtained information was used to propose novel catalytic mechanism of Aβ peptide degradation by aminopeptidase (SGAK). This study gives fundamental information to understand substrate recognition and degradation of Aβ-peptide by aminopeptidase (SGAK) to develop new therapeutic strategies in Alzheimer’s disease this study is published in amino acid journal. Similarly role of cysteine protease from Xanthomonas campestris in Aβ peptide degradation was studied and this work was published in Computers in Biology and Medicine. This article ranked 21th on the top 25 hottest searched articles for computers in biology and medicine in 2014. The isolated Streptomyces regensis MK was used for the production of aminopeptidase. The purified aminopeptidase from Streptomyces regensis MK was having potential to degrade Aβ peptide and this part is ready to communicate. Overall his research is focused on the understanding Aβ peptide degradation mechanism using experimental and computational studies. He had published a book chapter entitled “Molecular Docking Technique to Understand Enzyme-Ligand Interactions” in the Book “Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery” edited by IGI Global Iran. In his research he had published 17 papers. His future research plans are to work in computational biology and drug designing. He has a huge interest in field of drug designing to search novel drugs by using bioinformatics techniques and validate them by experimentally.
His future research plans are to work in the field of computational biology and drug designing.He has a huge interest in field of drug designing to search novel drugs by using bioinformatics techniques and validate them experimentally. Also the drugs which are tested by experimental methods can be further validated by computational methods such as molecular docking and MD simulation studies. He was interested in doing molecular docking and MD simulation studies to solve the problem that lead to any disease by understanding the basic mechanism behind the disease at the molecular level. Similarly he is having an interest in enzyme purification and its further application. However he can work on both the experimental and computational aspects of any protein or enzymes so it would be helpful to design the specific drug against the target enzyme. His research objectives are identification of new enzymatic targets in different disease, then experimental and computational studies to find the possible drug against such targets. Optimisation studies of the identified drugs against the target enzymes using dry and wet lab experiments.