Dr. Cinzia Giagulli obtained in 1997 the Biological Science degree and then completed PhD in “Molecular and Cellular Biology and Pathology” at Verona University. In this period she worked on signal transduction pathways which control integrin activation by chemokines during leukocyte recruitment, a process involved in supporting the antimicrobial response, but also in the pathogenesis of several human diseases, such inflammation, autoimmune, allergic and vascular diseases, transplant rejection and cancer. She continued postdoctoral studies at Verona and Brescia University School of Medicine studying in particular “Cellular Biology and Proteomic Analysis in System Biology”. In 2011 she obtained the Specialization in Microbiology and Virology and at the moment is responsible of molecular diagnostic of viral and bacterial infections in the Microbiology Laboratory of Civil Hospital Campus (Brescia). At present, as scientist in Microbiology and Clinic Microbiology at the University of Brescia, she’s studying virus/host interactions and, in particular, the biological activity on HIV-1 matrix protein p17 and its variants on immune cells and their role in HIV-1 pathogenesis. Recently, she is involved in research projects aimed to understand by structure-function studies how mutations in the p17 amino acid sequence are linked to B cell growth and tumorigenesis and by phosphoproteome studies the signaling cascades responsible of this effect. He has published more than 36 papers in peer-reviewed journals and serves as an editorial board member for diverse Journals.
The complex host/pathogens interactions and determine the involvement of chemokines and chemokine receptors in the pathogenesis of inflammatory and infectious diseases as well as in cancer.