Dr. Suhas Sampat Kharat, currently working as a postdoctoral fellow at the National Cancer Institute, National Institute of Health, Frederick, MD, USA. He has reviewed articles for many journals, some of them are Cancer Letters, Plos One and BMC Genetics, Nutrients, FASEB Journal, PeerJ, Cellular Reprogramming. His doctoral study was carried out in Signal Transduction Laboratory at the National Institute of Immunology, New Delhi. The major focus of his thesis was investigating the combinatorial effect of various post-translational modifications in regulating the stability and functions of tumor suppressor BLM helicase and p53. This project focused on elucidating the role of SCF-Fbw7 E3 ligase in regulating the stability of BLM helicase and p53. Apart from his Ph.D. thesis work, he has been fortunate to work on multiple collaborative projects within the lab as well as with various research groups from other institutions, which has provided him an excellent opportunity to develop a good understanding of multiple aspects of genome integrity and its role in tumorigenesis. His current project as a postdoctoral fellow at National Cancer Institute, NIH focusses on epigenetic regulation of replication fork stability and chemoresistance and his current study has identified the role of replication fork stability in mediating chemoresistance in BRCA2 deficient cells.
The research interest of Dr. Suhas Sampat Kharat is in DNA replication, DNA metabolism, Epigenetics, DNA damage and repair, DNA metabolism, DNA modification, Cell Cycle and other allied fields of DNA repair biology. Post-translational modification, Cancer, Stem Cells