Acta Scientific Women's Health

Research Article Volume 2 Issue 1

Gum Arabic Increases Hypothalamic POMC mRNA Expression Associated with Decreased Plasma Lipids Profile in Mice

Abdelkareem A Ahmed1-3*, Eltayeb Tayrab4, Adriano Mollica5, Azzurra Stefanucci5, Mohammed Elmujtba Adam Essa1, Hussein Ahmed6

1Department of Phytochemistry and herbal Medicine, Medical and Cancer Research Institute (MCRI), Nyala, South Darfur, Sudan

2Department of Physiology and Biochemistry, Faculty of Veterinary Science, University of Nyala, Nyala, Sudan

3Biomedical Research Institute, Darfur University College, Nyala, Sudan

4Department of Chemical Pathology, Faculty of Medical Laboratory Sciences, National Ribat University, Khartoum, Sudan

5Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy

6College of Veterinary and Animal Science, the Islamia University, Bahawalpur, Pakistan

*Corresponding Author: Abdelkareem A Ahmed, Department of Physiology and Biochemistry, Faculty of Veterinary Science, University of Nyala, Nyala, Sudan.

Received: November 11, 2019; Published: December 06, 2019

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Abstract

Objectives:Obesity is a worldwide health concern linked with high morbidity and mortality. Therapeutic strategies such as surgical operation and synthetic drugs ultimately cause high costs and serious complications. The anti-obese effect of dietary fiber is usually accepted to reduce body weight gain. Gum Arabic (GA) Acacia senegal used as a dietary fiber to reduce body weight.

Aim: The aim was to study the effects of GA on visceral adipose tissue (VAT) and its relation with hypothalamic expression of energy homeostasis related genes. We offered GA to 90 days old female mice in drinking water (10% w/v) for 84 days. Food consumption, body weight, plasma glucose, plasma lipid profile, plasma leptin, PYY and GLP-1 and mRNA of pro-opiomelanocortin (POMC) were measured. GA in drinking water significantly (P<0.05) decreased food intake associated with reduction of body weight and VAT accumulation compared to control. In addition, GA significantly (P<0.05) decreased plasma glucose, plasma total cholesterol, LDL and VLDL whereas increased HDL compared to control. The treatment of GA significantly increased plasma PYY and GLP-1 concentration whereas decreased leptin concentrations compared to the control. Moreover, GA significantly increased hypothalamic expression of POMC mRNA. However, GA treatment did not alter plasma triglycerides.

Conclusion: We conclude that GA decreases food intake, reduces body weight, as well as plasma lipids associated with reduction of VAT. GA also increases plasma PYY and GLP-1 concentration and on hypothalamic expression of POMC mRNA.

KeywordsGum Arabic; Pro-Opiomelanocortin; Hypothalamus; Mice

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Citation

Citation: Abdelkareem A Ahmed., et al. "Gum Arabic Increases Hypothalamic POMC mRNA Expression Associated with Decreased Plasma Lipids Profile in Mice".Acta Scientific Women's Health 2.1 (2020): 08-14.




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