Sayyed Abbas Datlibeigi¹, Amir Abdolmaleki², Parisa Abbasi³ and Amene Nikgoftar Fathi⁴*

¹Department of Anatomical Sciences, Medical School, Yazd University of Medical Sciences, Yazd, Iran
²Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
³Department of Surgical Technology, Paramedic School, Hamedan University of Medical Sciences, Hamedan, Iran
⁴Department of Anatomical Sciences, Medical School, Arak University of Medical Sciences, Arak, Iran

*Corresponding Author: Amene Nikgoftar Fathi, Department of Anatomical Sciences, Medical School, Arak University of Medical Sciences, Arak, Iran.

Received: April 23, 2021; Published: May 26, 2021

Abstract

  Amitriptyline (Ami) as a tricyclic antidepressant drug is widely used globally. Pituitary-gonadal hormonal axis with various hormones is affected by many antidepressant drugs. Thus in this experimental research, we aimed to assess the probable effects of Ami with various doses on serum levels of female sexual and gonadotropin hormones. 35 female mice (25 - 30 gr, 8 - 12 weeks old) were categorized into 5 groups (n = 7); control (received no treatments), sham (treated with 0.2 ml of distilled water), and three experimental groups (Ami 50, 75, and 100 mg/kg). Treatments were administrated orally for 4 weeks. A day following experiment, the animals were weighted and sacrificed by cervical dislocation. Thoracotomy procedure was applied and the blood was aspirated (1 ml) from right ventricle to measure blood serum levels of LH, FSH, estrogen and progesterone using ELISA assay. Animals treated with various doses of Ami represented significant (p < 0.05) decreased levels of estrogen (with the dose of 75 and 100 mg/kg Ami) and progesterone (with the doses of 100 mg/kg Ami). Also, serum levels of FSH (with the doses of 75 and 100 mg/kg Ami) showed increased trend significantly (p < 0.05). No significant (p > 0.05) differences were found in total animal body weight and serum levels of LH following Ami administration with whole doses. Ami is potentially able to reduce female sexual hormones (estrogen and progesterone) in mice with no effects on gonadotropin hormones. This fluctuation in sexual hormones probably can lead to disruption in female reproductive functions.

Keywords: Amitriptyline; Mice; Estrogen; Progesterone; FSH; LH

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Citation

Citation: Amene Nikgoftar Fathi., Aet al. “Amitriptyline Prescription Can Potentially Affect Pituitary-Gonadal Hormonal Axis in Female Mice”. Acta Scientific Women's Health 3.6 (2021): 120-123.

Copyright

Copyright: © 2021 Amene Nikgoftar Fathi., Aet al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.