Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 1

Comparative Analyses of Gene Expression Profiles Following Exercise - and Electrical Stimulation - Induced Improvement of Walking Performance in Rat Claudication Model

Momoko Shiragaki-Ogitani1*, Keita Kono2, Futoshi Nara3 and Atsushi Aoyagi1

1Specialty Medicine Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan
2Specialty Medicine Laboratories I, Daiichi Sankyo Co., Ltd., Tokyo, Japan
3Ube Industries. Ltd. Pharmaceuticals Research Laboratory, Japan

*Corresponding Author: Momoko Shiragaki-Ogitani, Specialty Medicine Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan.

Received: December 18, 2019; Published: December 26, 2019

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Abstract

  Exercise is considered to be the most efficacious therapeutic approach for improving walking capacity in patients with intermittent claudication (IC). Despite its enormous benefits, the underlying mechanisms remain unclear. To reveal the local mechanisms underlying exercise-induced improvement in walking performance, we previously developed an electrical stimulation (ES) model which exerts local limb muscle contraction that mimics exercise training. This prior study showed ES-induced improvement of walking performance in a rat IC model. In the present study, we confirmed gene expression profiles following hind-limb ischemia, and recovery following exercise or ES-intervention using GeneChip microarray in a rat IC model. Of the top 40 genes upregulated or downregulated following exercise and ES compared with hind-limb ischemia, most genes changed in opposite directions to sham-operated normal control. We further confirmed the gene expression changes using semi-quantitative real-time PCR, and identified several candidates that might potentially be involved in the improvement of walking performance following exercise or ES including Dpp4, Nov, and Ptges. Further analyses of gene expression profiles and characterization of individual genes will help in the identification of therapeutic targets for the treatment of patients with IC.

Keywords: Intermittent Claudication; Exercise; Electrical Stimulation; Mechanism; Transcriptional Analysis

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References

  1. Insight Report titled The Inclusive Growth and Development Report. World Economic Forum (2017).
  2. De Soto H. The Mystery of Capital: Why Capitalism Triumphs in the West and Fails Everywhere Else. New York: Basic Books (2000).
  3. Prahalad CK. “The fortune at the bottom of the pyramid: Eradicating poverty through profits”. New Delhi: Pearson Education and Wharton School (2005).
  4. WHO Technical Discussions. Appropriate Health Technology (1997).
  5. Annies, A. Current Issues and Challenges in Managing Government’s Assets and Facilities (2007).
  6. Czaja SJ., et al. “Factors predicting the use of technology: findings from the Center for Research and Education on Aging and Technology Enhancement (CREATE)”. Psychology and aging 21 (2006): 333-352.
  7. Perkins R and Neumayer E. “The International Diffusion of New Technologies: A Multi-Technology Analysis of Latecomer Advantage and Global Economic Integration”. Annals of the Association of American Geographers 95 (2005): 789-808.
  8. World Bank Report. Future of Food Harnessing Digital Technologies to Improve Food System Outcomes (2019).
  9. Zanello G., et al. “Innovation under the radar in low-income countries: Evidence from Ghana”. PowerPoint presentation from UNU-WIDER Conference, Helsinki, Finland. Oxford: Oxford Department of International Development (2013).
  10. Belliveau J. Three Most Common Healthcare Supply Chain Management (2017).
  11. Chemonics. Cutting-edge Technologies in Global Health Supply Chains (2016).
  12. Mathew J., et al. New Trends in Healthcare Supply Chain, POMS 24th Annual Conference “Integrating Practice in POM Research and Teaching”. (2013).
  13. Riungu JM. “Innovations in pharmaceutical supply chains in sub-Saharan Africa”. Pharmalink 11 (2011).
  14. Dobrovnik M., et al. “Blockchain for and in Logistics: What to Adopt and Where to Start”. Logistics 2 (2018): 18.
  15. Crosby PB. Quality Is Free: The Art of Making Quality Certain. McGraw-Hill, New York (1979).
  16. Paulk MC., et al. “Capability Maturity Model for Software, Version 1.1’, Carnegie Melon University (1993): 82.
  17. Handfield RB and Nicholas Jr EL. “Supply Chain Redesign: Converting Your Supply Chain into Integrated Value Systems”. Financial Prentice Hall, New York (2002).
  18. Bowersox DJ., et al. Supply Chain Logistics Management [Electronic version], McGrawHill, New York 200 (2002).
  19. Bessant J., et al. “Putting supply chain learning into practice". International Journal of Operations and Production Management 23 (2003): 167-184.
  20. Lee LL and Billington C. “The evolution of supply chain management models and practice at Hewlett-Packard”. Interfaces 25 (1995): 42-63.
  21. Chan FTS and Qi HF. “An innovative performance measurement method for supply chain management”. Supply Chain Management: An International Journal 8.3 (2003): 209-223.
  22. Lahti M., et al. “Developing a maturity model for Supply Chain Management”. International Journal of Logistics Systems and Management 5.6 (2009): 654-678.
  23. Gunasekaran A., et al. “Performance measurement and metrics in a supply chain environment”. International Journal of Operations and Production Management 21 (2001): 71-87.
  24. Gordon S. “Supply-chain operations reference model (SCOR): the first cross-industry framework for integrated supply-chain management”. Logistics Information Management 10.2 (1997): 62-67.
  25. Poirier CC and Quinn FJ. “How are we doing: A survey of supply chain progress”. Supply Chain Management Review (2004).
  26. Lockamy A and McCormack K. “The development of a supply chain management process maturity model using the concepts of business process orientation”. Supply Chain Management: An International Journal 9.4 (2004): 272-278.
  27. Pamela Steele Associates. White paper titled Supply Chain Maturity in Frontier Markets: Using the Frontier Markets Supply Chain Maturity Model to Improve Supply Chain Performance in Resource-Constrained Environments (2019).
  28. Goodman J. Linking Mobile Phone Ownership and Use to Social Capital in Rural South Africa and Tanzania. Vodafone Policy Paper Series 3 (2005).
  29. Prahalad CK and Hamel G. “The Core Competence of the Corporation”. Harvard Business Review (1990): 79-91.
  30. Edwards-Schachter M. “The nature and variety of innovation”. International Journal of Innovation Studies 2.2 (2018): 65-79.
  31. Koruna S. “Leveraging Knowledge Assets: Combinative Capabilities—Theory and Practice”. Research and Development Management 34 (2004): 505-516.
  32. Coyle D. “Overview” In Vodafone, “Africa: The Impact of Mobile Phones. Vodafone Policy Paper 2. London (2005).
  33. Scott N., et al. “The Impact of Mobile Phones in Africa”. Paper prepared for the Commission for Africa, London (2004).
  34. Samuel J., et al. “Mobile Communications in South Africa, Tanzania and Egypt: Results from Community and Business Surveys”. In Vodafone, “Africa: The Impact of Mobile Phones”. Vodafone Policy Paper 2. London (2005).
  35. McKemey K., et al. Innovative Demand Models for Telecommunications Services. Technical report. UK Department for International Development, London (2003).
  36. Grossman GM and Elhanan H. "Endogenous Innovation in the Theory of Growth”. Journal of Economic Perspectives 8 (1994): 23-44.
  37. Driffield N and Love JH. “Linking FDI motivation and host economy productivity effects: Conceptual and empirical analysis”. Journal of International Business Studies 38.3 (2007): 460-473.
  38. Dosi G. Technical Change and Industrial Transformation, London, Macmillan (1984).
  39. Zahra SA and George G. “Absorptive Capacity: A Review, Reconceptualization, and Extension,” Academy of Management Review 27 (2002): 185-203.
  40. Mowery DC and Oxley JE. “Inward technology transfer and competitiveness: the role of national innovation systems’’. Cambridge Journal of Economics 19.1 (1995): 67-84.
  41. Abdussamet P and Osman D. “An investigation of healthcare supply chain management and patient responsiveness”. International Journal of Pharmaceutical and Healthcare Marketing 12 (2018): 325-347.
  42. Challenges, Practice Management News.
  43. Gjoko M. “Paradigm Shift: Report on the New Role of Design in Business and Society”. She Ji: The Journal of Design, Economics, and Innovation 1.2 (2015): 118-139. 
  44. Lane PJ and Lubaktin M. “Relative Absorptive Capacity and Interorganizational Learning”. Strategic Management Journal 19 (1998): 461-477.
  45. Witold JH and Bennet AZ. “The Hidden Risks in Emerging Markets”. Harvard Business Review (2010).
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Citation

Citation: Momoko Shiragaki-Ogitani., et al. “Comparative Analyses of Gene Expression Profiles Following Exercise - and Electrical Stimulation - Induced Improvement of Walking Performance in Rat Claudication Model". Acta Scientific Pharmaceutical Sciences 4.1 (2020): 67-74.



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