Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 6 Issue 3

Comparative Effect of Atorvastatin and Rosuvastatin in cardiovascular Diseased patients

Sravan Kumar1*, R Yashaswini2, Prashanthi Gundlapally3 and Sireesha Althapu4

1Department of Clinical Operations, Archeron Clinical Solutions, India
2Pharm-D, Nirmala college of Pharmacy, India
3Clinical Research Associate, Teva Pharmaceuticals, India
4Clinical Research Coordinator, IQVIA, India

*Corresponding Author: Sravan Kumar, Department of Clinical Operations, Archeron Clinical Solutions, India.

Received: January 31, 2022; Published: February 18, 2022

Abstract

Aim: The purpose of the study is to compare the effectiveness of Atorvastatin and Rosuvastatin in cardiovascular disease patients.

Objectives:

  • Comparision of Atorvastatin and Rosuvastatin in cardiovascular patients.
  • Assessing and managing the cardiovascular disease.
  • Monitoring the adverse effects, drug interactions, food interactions in cardiovascular disease patients.
  • Assessing the complications and consequences reported by the patients.
  • Counselling the cardiovascular patients about their disease and management.
  • Compare the efficacy of equivalent doses of Rosuvastatin and Atorvastatin in lowering LDL –C levels.
  • Compare the cost effectiveness of Rosuvastatin and Atorvastatin therapy.

Methodology: A prospective observational study was carried out at Departments of in and outpatients at Sai Srinivasa Hospital and Fathima Institute of Medical Sciences, for a period of 6 months (September 2018 to February 2019). All the patients who are diagnosed with cardiac problems were included in this study. Patients between ages of 30 - 70 yrs were considered. Patients with Pregnant, lactating, childrens, Diabetes Mellitus, Thyroid & Other than cardiovascular disease patients were excluded in the study.

Results: During the study 80 cases were recorded from SEP 2018 to FEB 2019 Among 80 patients, the incidence of CVD with hyperlipidemia was more at the age of 51-60 years in males. In the Atorvastatin group a decrease of 5.5% in LDL.C levels from that of base line mean LDL-C level was seen. In the Rosuvastatin group a decrease of 14.55% in LDL.C levels from that of base line mean LDL-C levels was seen, the difference in reduction being 9.0%.

In the Atorvastatin group there was 1.71% increase of HDL-C levels from that of mean base line HDL-C levels was seen. In the Rosuvastatin group the increase of HDL-C levels was only 0.4% from that of mean base line HDL-C levels. The difference in increase was more in Atorvastatin group, the difference being 1.31%.

 There was significant decrease in LDL –C level (P < 0.001) in Rosuvastatin group. So, this study shows that Rosuvastatin 10 mg/day is more effective than Atorvastatin 10 mg/day in lowering LDL-C levels in patients with Hypercholesterolemia.

Conclusion: Dyslipidemia is the most common co-morbid condition associated with cardiovascular disease.

The study was able to describe the comparative effect of Atorvastatin verses Rosuvastatin. Atorvastatin and Rosuvastatin have potent lipid lowering effect, but the spectrum of adverse effects is different in both the drugs. Hence Rosuvastatin is better to lower the LDL cholesterol than Atorvastatin. Atorvastatin is better to increase HDL cholesterol than Rosuvastatin, but both the drugs have their own limitations. So, by comparing the effect of both drugs, Rosuvastatin was recommended for patients having Hepato-toxicity disorders. Atorvastatin was recomended for patients who had complaints of myopathy.

This study shows that Rosuvastatin is more cost effective compared to Atorvastatin.

Keywords: Hyperlipidemia; CVD; Lipid Profile

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Citation

Citation: Sravan Kumar. “Comparative Effect of Atorvastatin and Rosuvastatin in cardiovascular Diseased patients". Acta Scientific Pharmaceutical Sciences 6.3 (2022): 02-08.

Copyright

Copyright: © 2022 Sravan Kumar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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