Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 4

Development of Azithromycin Ophthalmic Gels Using Various Polymers

Harith Salam Mohammed, Ahmad Makame Mwadini, Nida’a Mohammed Ali Wadi and Alka Ahuja*

College of Pharmacy, National University of Science and Technology, Muscat, Sultanate of Oman, Oman

*Corresponding Author: Alka Ahuja, Professor of Pharmaceutics, College of Pharmacy, National University of Science and Technology, Oman.

Received: February 27, 2020; Published: March 17, 2020

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Abstract

  Different formulations for the treatment of eye infections are usually administered in the form of conventional ocular drug delivery systems which are topical eye drops or ointments (1). Typically, ophthalmic bioavailabilities of only 1 - 10% are achieved due to the short precorneal residence time of ophthalmic solutions. (2) The preparation and evaluation of gel containing antibiotic azithromycin combined with different polymers like Carbopol, sodium alginate and Hydroxypropyl cellulose (HPC) was done and assessed to find out which polymer could best be used in preparing ophthalmic gels for this antibiotic using factorial design. Since the efficacy of these gels is dependent on factors like viscosity and pH, the polymers in these gels were also examined for different parameters such as pH, in vitro release, permeation and microbiological evaluation.

Keywords: Drug; Ophthalmic Gels; Eye Drops

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References

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Citation

Citation: Alka Ahuja., et al. “Development of Azithromycin Ophthalmic Gels Using Various Polymers". Acta Scientific Pharmaceutical Sciences 4.4 (2020): 48-54.



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