Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 4

Rapid Spectrophotometric Methods for the Determination of Moxifloxacin and Sildenafil in Pharmaceutical Preparations Based on Reaction with 4-Aminoantipyrine

Safwan Ashour*

Faculty of Engineering, University of Gaziantep, Gaziantep, Turkey

*Corresponding Author: Safwan Ashour, Faculty of Engineering, University of Gaziantep, Gaziantep, Turkey.

Received: January 28, 2020; Published: March 09, 2020

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Abstract

  Two simple and rapid spectrophotometric methods by the application of oxidative coupling reactions in aqueous medium for the determination of moxifloxacin hydrochloride (MOXF) and sildenafil citrate (SC) in either pure form or in its pharmaceutical preparations have been carried out. MOXF and SC react with 4-aminoantipyrine in the presence of KIO4 to yield red colored products exhibit maximum absorption at 530 and 526 nm for MOXF and SC, respectively. Beer's law plot showed linear relationship in the concentration ranges 2.65 - 230.0 and 1.66 - 98.0 µg/mL with detection limit of 0.55 and 0.44 µg/mL for MOXF and SC, respectively. Molar absorptivity for the above two methods were found to be 4.40×103 and 8.25×103 L/mol cm, respectively. The developed methods were applied to estimate MOXF and SC in tablets dosage form and the results compare favorably with those of pharmacopeial methods. Both the methods are accurate, precise and highly reproducible, cheap, rapid and suitable applied for routine analysis of MOXF and SC in bulk and formulations.

Keywords: 4-Aminoantipyrine; Moxifloxacin Hydrochloride; Sildenafil Citrate; Oxidative Coupling Reactions; Spectrophotometry; Dosage Forms

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Citation

Citation: Safwan Ashour. “Rapid Spectrophotometric Methods for the Determination of Moxifloxacin and Sildenafil in Pharmaceutical Preparations Based on Reaction with 4-Aminoantipyrine".Acta Scientific Pharmaceutical Sciences 4.4 (2020): 02-10.



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