Sankha Bhattacharya*
Associate Professor, Department of Pharmaceutics, ISF College of Pharmacy, Punjab, India
*Corresponding Author: Sankha Bhattacharya, Associate Professor, Department of Pharmaceutics, ISF College of Pharmacy, Punjab, India.
Received: January 31, 2019; Published: February 08, 2020
Now a day’s cationic lipid has become an essential and vital tool for transferring DNA into the cytocellular membrane [1]; which is ultimately helps in gene therapy. In this direction, cationic lipids are being mixed with DNA to form cationic lipid DNA complex or Lipoplexes [2]. For in vivo applications of Lipoplexes, it is precondition to have excess positive and excess negative charge ratio for gene transfer [3]. Although Lipoplexes are good carrier for gene therapy, but actual transfection activity is not clear for Lipoplexes [4]. For making Lipoplexes a stable formulation, it is necessary to have proper lipid and DNA charge ratio in it [5]. The Figure 1 explaining the morphology and cytocellular behaviour of Lipoplexes.
Citation: Sankha Bhattacharya. “Cationic Lipoplexes and its Bourgeoning Mechanisms; an Expert Opinion". Acta Scientific Pharmaceutical Sciences 4.3(2020): 13-14.
Copyright: © 2020 Mohd Sankha Bhattacharya. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Copyright