Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Short Communication Volume 4 Issue 3

Cationic Lipoplexes and its Bourgeoning Mechanisms; an Expert Opinion

Sankha Bhattacharya*

Associate Professor, Department of Pharmaceutics, ISF College of Pharmacy, Punjab, India

*Corresponding Author: Sankha Bhattacharya, Associate Professor, Department of Pharmaceutics, ISF College of Pharmacy, Punjab, India.

Received: January 31, 2019; Published: February 08, 2020


  Now a day’s cationic lipid has become an essential and vital tool for transferring DNA into the cytocellular membrane [1]; which is ultimately helps in gene therapy. In this direction, cationic lipids are being mixed with DNA to form cationic lipid DNA complex or Lipoplexes [2]. For in vivo applications of Lipoplexes, it is precondition to have excess positive and excess negative charge ratio for gene transfer [3]. Although Lipoplexes are good carrier for gene therapy, but actual transfection activity is not clear for Lipoplexes [4]. For making Lipoplexes a stable formulation, it is necessary to have proper lipid and DNA charge ratio in it [5]. The Figure 1 explaining the morphology and cytocellular behaviour of Lipoplexes.



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Citation: Sankha Bhattacharya. “Cationic Lipoplexes and its Bourgeoning Mechanisms; an Expert Opinion". Acta Scientific Pharmaceutical Sciences 4.3(2020): 01-02.

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