Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Short Communication Volume 4 Issue 3

Cationic Lipoplexes and its Bourgeoning Mechanisms; an Expert Opinion

Sankha Bhattacharya*

Associate Professor, Department of Pharmaceutics, ISF College of Pharmacy, Punjab, India

*Corresponding Author: Sankha Bhattacharya, Associate Professor, Department of Pharmaceutics, ISF College of Pharmacy, Punjab, India.

Received: January 31, 2019; Published: February 08, 2020

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  Now a day’s cationic lipid has become an essential and vital tool for transferring DNA into the cytocellular membrane [1]; which is ultimately helps in gene therapy. In this direction, cationic lipids are being mixed with DNA to form cationic lipid DNA complex or Lipoplexes [2]. For in vivo applications of Lipoplexes, it is precondition to have excess positive and excess negative charge ratio for gene transfer [3]. Although Lipoplexes are good carrier for gene therapy, but actual transfection activity is not clear for Lipoplexes [4]. For making Lipoplexes a stable formulation, it is necessary to have proper lipid and DNA charge ratio in it [5]. The Figure 1 explaining the morphology and cytocellular behaviour of Lipoplexes.

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References

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  11. Audouy S., et al. “Serum as a modulator of lipoplex‐mediated gene transfection: dependence of amphiphile, cell type and complex stability”. The Journal of Gene Medicine: A cross‐disciplinary journal for research on the science of gene transfer and its clinical applications 2.6 (2000): 465-476.
  12. Lonez C., et al. “Cationic liposomal lipids: from gene carriers to cell signalling”. Progress in Lipid Research 47.5 (2008): 340-347.
  13. Adikwu MU and CO Esimone. “Biopolymers in drug delivery: recent advances and challenges”. 2010: Bentham Science Publishers (2010).
  14. Elouahabi A and JM Ruysschaert. “Formation and intracellular trafficking of lipoplexes and polyplexes”. Molecular therapy 11 (2005): 336-347.
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Citation

Citation: Sankha Bhattacharya. “Cationic Lipoplexes and its Bourgeoning Mechanisms; an Expert Opinion". Acta Scientific Pharmaceutical Sciences 4.3(2020): 01-02.



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