Harshala M Chachare, Neha S Pawar and Vivekanand K Chatap*
Post Graduate Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India
*Corresponding Author:Vivekanand K Chatap, Assistant Professor, Post Graduate Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.
Received: August 27, 2018; Published: September 06, 2018
Citation: Vivekanand K Chatap., et al. “Fabrication and Characterization of Lornoxicam Loaded Microsponge Tablets for Colon Delivery”. Acta Scientific Pharmaceutical Sciences 2.10 (2018).
AIn present investigation first attempt was made to developed lornoxicam (LXM) loaded microsponges prepared by quasi emulsion solvent diffusion technique, by using ethyl cellulose in different concentrations. Microsponges were evaluated for percentage yield, encapsulation efficiency, drug content, surface morphology. Optimized batch of microsponges was further formulated as tablet for colon delivery. In-vitro dissolution study of tablets was performed under sink condition with and without caecal contents. Microsponge tablet showed drug release after 8th hour corresponding to the arrival time in proximal colon and drug release of 81.28% up to 24 hrs. From this study, it can be concluded that, microsponges is an advance combined approach of both the triggering mechanism of microflora-activation and avoiding release in the small intestine.
Keywords: Lornoxicam; Microsponge; Quasi Emulsion Solvent Diffusion Technique and Microsponge Tablet
Copyright: © 2018 Vivekanand K Chatap., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.