Acta Scientific Pharmaceutical Sciences

Short CommunicationVolume 2 Issue 9

Drug Discovery by Computer Chemistry Using Molecular Docking

Bouchentouf Salim1,2*

1Faculty of Technology, University of Doctor Tahar Moulay of Saida, Algeria
2Laboratory of Natural Products and Bioactives, Tlemcen University, Algeria

*Corresponding Author: Bouchentouf Salim, Faculty of Technology, University of Doctor Tahar Moulay of Saida and Laboratory of Natural Products and Bioactives, Tlemcen University, Algeria.

Received: July 23, 2018; Published: August 14, 2018

Citation: Bouchentouf Salim. “Drug Discovery by Computer Chemistry Using Molecular Docking”. Acta Scientific Pharmaceutical Sciences 2.9 (2018).

  Drug design plays a very important role in today's world of medical science. Significant amounts are invested each year in the private and government sectors to design new or improved drugs to target a new disease or simply to take part of an already existing market by bringing a new product. Different approaches to designing a drug may differ in methodology to achieve an accepted and marketable product. Several disciplines of science are solicited in this long process; biochemistry and organic chemistry, molecular biology, pharmacology, bioinformatics and statistics, physical chemistry and computer chemistry etc.

  Before considering any new drug the first question that needs to be answered is how we are going to affect the target of the molecular process causing the disease. It is important to minimize the impact of the drug on metabolic processes, so high specificity must define the interaction between the target and the drug. Given the limited time frame and the huge sums of money at stake, an empirical method of trial and error, such was the approach a few decades ago, is by no means the best method to influence the therapeutic target. How then proceed in a non-empirical way?

Copyright: © 2018 Bouchentouf Salim. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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