School of Pharmaceutical Technology, Adamas University, India
*Corresponding Author: Arindam Maity, School of Pharmaceutical Technology, Adamas University, India.
Received: June 11, 2018; Published: July 01, 2018
Citation: Arindam Maity.“Mesoionic Compounds and its Application in Organic and Pharmaceutical Field”. Acta Scientific Pharmaceutical Sciences 2.8 (2018).
Compounds of the mesoionic class have interesting structural features provided by their betaine-like character. Mesoionic compounds (MICs) consist of a five-membered heterocyclic ring associated with a sextet of p and π electrons, in which both positive and negative charges are delocalized, have been known for more than a century [1,5]. In recent times, MICs have attracted the attention of chemists particularly because of the bonding aspects associated with their unusual structure which can be regarded as mesomeric heterocyclic betaines, strongly stabilized by π-electron delocalization and having large dipole moments . The association of these characteristics suggests a high probability of strong interactions with biomolecules such as DNA and/or proteins . Although mesoionic compounds are internally charged, they are neutral overall, and can therefore cross biological membranes in vivo . The synthetic approaches to mesoionic heterocycles by 1,3 dipolar cycloaddition reactions are mostly those concerning münchnones (1,3-oxazolium-5-olates) and the newer isomünchnones (1,3-oxazolium-4-olates). Some work involving the mesoionic sydnones (1,2,3-oxadiazolium-5-olates), thiomünchnones (1,3-oxathiolium5-olates) and thioisomünchnones (1,3-thiazolium-4-olates) have also appeared [9-12].
Copyright: © 2018 Arindam Maity. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.