Acta Scientific Pharmaceutical Sciences

EditorialVolume 2 Issue 8

Mesoionic Compounds and its Application in Organic and Pharmaceutical Field

Arindam Maity*

School of Pharmaceutical Technology, Adamas University, India

*Corresponding Author: Arindam Maity, School of Pharmaceutical Technology, Adamas University, India.

Received: June 11, 2018; Published: July 01, 2018

Citation: Arindam Maity.“Mesoionic Compounds and its Application in Organic and Pharmaceutical Field”. Acta Scientific Pharmaceutical Sciences 2.8 (2018).

   Compounds of the mesoionic class have interesting structural features provided by their betaine-like character. Mesoionic compounds (MICs) consist of a five-membered heterocyclic ring associated with a sextet of p and π electrons, in which both positive and negative charges are delocalized, have been known for more than a century [1,5]. In recent times, MICs have attracted the attention of chemists particularly because of the bonding aspects associated with their unusual structure which can be regarded as mesomeric heterocyclic betaines, strongly stabilized by π-electron delocalization and having large dipole moments [6]. The association of these characteristics suggests a high probability of strong interactions with biomolecules such as DNA and/or proteins [7]. Although mesoionic compounds are internally charged, they are neutral overall, and can therefore cross biological membranes in vivo [8]. The synthetic approaches to mesoionic heterocycles by 1,3 dipolar cycloaddition reactions are mostly those concerning münchnones (1,3-oxazolium-5-olates) and the newer isomünchnones (1,3-oxazolium-4-olates). Some work involving the mesoionic sydnones (1,2,3-oxadiazolium-5-olates), thiomünchnones (1,3-oxathiolium5-olates) and thioisomünchnones (1,3-thiazolium-4-olates) have also appeared [9-12].

Copyright: © 2018 Arindam Maity. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Member In



News and Events


  • Submission Timeline for Regular Issue
    Last date for submission of articles for regular Issues is October 30, 2019.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US