Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 6

Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Fosfomycin in Bulk and Tablet Dosage Form

Dhananjay M Patil*, Sapana S Chaudhary, Vinod A Bairagi and Rakesh M Bachhav

Department of Pharmaceutics, K.B.H.S.S. Trust’s Institute of Pharmacy, Malegaon-Camp, Malegaon, Maharashtra, India

*Corresponding Author: Dhananjay M Patil, Department of Pharmaceutics, K.B.H.S.S. Trust’s Institute of Pharmacy, Malegaon-Camp, Malegaon, Maharashtra, India.

Received: February 24, 2018; Published: May 11, 2018

Citation: Dhananjay M Patil., et al. “Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Fosfomycin in Bulk and Tablet Dosage Form”. Acta Scientific Pharmaceutical Sciences 2.6 (2018).

Abstract

  A simple, reproducible, robust and precise as well as cost effective stability indicating UV spectrophotometric method has been developed of Fosfomycin in bulk and pharmaceutical formulations. The maximum UV spectrum wavelength is 254 nm by scanned in the range of 200 to 400 nm of Fosfomycin stock solution. The obeyed Beer’s law in the concentration range of 05 - 25 μg/ml. The Fosfomycin subjected to forced degradation studies includes are the extremely unfavorable environmental and chemical conditions, were giving to the ICH guideline. And the results were found to be acceptable in range and application of this method was effectively in pharmaceutical dosage form without any interfering by the additive.

Keywords: Fosfomycin; Forced Degradation; UV Method; Validation; ICH Guidelines

Copyright: © 2018 Dhananjay M Patil., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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