Acta Scientific Pharmaceutical Sciences

EditorialVolume 2 Issue 5

Determination of Pharmaceutical Active Substances or their Metabolites in Biological Fluids

Mbah Chika John*

Lecturer, Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria

*Corresponding Author: Mbah Chika John, Lecturer, Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.

Received: March 01, 2018; Published: April 02, 2018

Citation: Mbah Chika John. “Determination of Pharmaceutical Active Substances or their Metabolites in Biological Fluids”. Acta Scientific Pharmaceutical Sciences 2.5 (2018).

  Biopharmaceutical analysis deals with the qualitative identification/confirmation and quantitative measurement of drugs or drug metabolites in biological fluids. The biological fluids include whole blood, plasma, serum, saliva, cerebrospinal fluid, urine etc. The qualitative identification/confirmation determines the organoleptic and physicochemical characteristics whereas quantitative analysis could be for bioequivalence, pharmacodynamics, pharmacokinetics, toxicokinetics purposes. Biopharmaceutical analysis also applies to drugs used for illicit purposes, forensic investigations, anti-doping testing in sports. This analytical technique unlike chemical analytical technique could face challenges arising from components of the sample matrix interfering with the analyte(s) of interest. Because these drugs/metabolites are in these complex and varied matrices, detection limits vary depending on the drug/metabolite. As the drugs/metabolites very often occur at very low concentrations (trace or ultra trace levels), sensitive and selective methods that are easily automated and within minimum pretreatment are preferable.

Copyright: © 2018 Mbah Chika John. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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