Department of Chemistry, Mehsana Urban Institute of Sciences, Ganpat University, Mehsana, Gujarat, India
*Corresponding Author: Prakash Prajapat, Department of Chemistry, Mehsana Urban Institute of Sciences, Ganpat University, Mehsana, Gujarat, India.
Received: February 03, 2018; Published: March 26, 2018
Citation: Anuradha Sharma. “An Overview of Ethics in Pharmaceutical Research”. Acta Scientific Pharmaceutical Sciences 2.4 (2018).
Combinatorial synthesis is a relatively recent innovation in medicinal and pharmaceutical chemistry. Essentially, it is an automated process by which large numbers of newer structure are synthesized on a small scale. There are two main approaches: Mix and Split method is also highly useful in the synthesis of mixture by combinatorial method. In this case each vial will contain different structures; structures will be physically distinct since each bead will only have a single product attached. Thus combinatorial libraries consist of structures that have been generated by combinatorial synthesis. Parallel combinatorial synthesis involves caring out the same reaction sequence on series of reactions vials but using different reactant and reagent for each vial. This allows rapid synthesis of large number of analogs based on common skeleton. It is useful in providing a series of compounds for studies into SAR. It is also useful in fine-tuning or optimizing a lead compound in order to find a structure with improved activity or reduced side effects. Combinatorial synthesis is also used to deliberately synthesize a mixture of compounds in each vial. In this situation, the structure attached to each individual bead will be identical, but different beads in the same vial will contain different structures. This form of combinatorial synthesis is useful in drug discovery where one is searching for a lead compound
Copyright: © 2018 Prakash Prajapat. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.