Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 4

Development and Validation of UV Spectrophotometric Method for Estimation of Felodipine Using Green Solvent in Tablet Formulation

Santosh S Chhajed*, Sandeep S Sonawane, Vaibhav P Patil, Jugal Mandan and Sanjay J Kshirsagar

Department of Pharmaceutical Chemistry, Mumbai Educational Trust’s Institute of Pharmacy, Nashik (MS), India

*Corresponding Author: Santosh S Chhajed, Department of Pharmaceutical Chemistry, Mumbai Educational Trust’s Institute of Pharmacy, Nashik (MS), India.

Received: February 08, 2018; Published: March 14, 2018

Citation: Santosh S Chhajed., et al. “Development and Validation of UV Spectrophotometric Method for Estimation of Felodipine Using Green Solvent in Tablet Formulation”. Acta Scientific Pharmaceutical Sciences 2.4 (2018).

Abstract

  In the present work simple fast, accurate precise and robust method for analysis of felodipine in its tablet dosage form is reported. Present method is developed by using less toxic and green solvent. Method is simple as requires no tedious sample preparation and hence can be used for routine analysis of felodipine in its tablet formulation. Method is developed at wavelength of maximum absor- bance 363.5 nm. The relative absorbance of the drug found to be proportional to the drug concentration in the linear ranges of 05 - 50 μgmL-1 for felodipine. The performance of the developed method was evaluated in terms of Standard deviation and relative standard deviation to find out the significance of proposed methods over the reference spectrophotometric method. Tablet formulations were successfully analyzed using the proposed method.

Keywords: Felodipine; Spectrophotometric Analysis; Method Validation; ICH

Copyright: © 2018 Santosh S Chhajed., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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