Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 1

Dissolution Improvement of Telmisartan by Surface Solid Dispersion Method

A Supriya*, B Manasa, TN Shilpa, Rajesh Kaza, S Savithramma and D Prasadu

Department of Pharmaceutics, Jawaharlal Nehru Technological University Anantapur, India

*Corresponding Author: A Supriya, Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University Anantapur, India.

Received: December 30, 2017; Published: January 11, 2018

Citation: A Supriya., et al. “Dissolution Improvement of Telmisartan by Surface Solid Dispersion Method”. Acta Scientific Pharmaceutical Sciences 2.1 (2018).

Abstract

 The present study was aimed to improve the aqueous solubility and bioavailability of telmisartan by Surface solid dispersion technique. Surface Solid dispersions of Telmisartan were prepared by using hydrophilic polymers such as Avicel PH101, Alginic acid and Aerosil200. In different weight ratios by solvent evaporation method. The drug and the solid dispersions were characterized by saturation solubility studies, in-vitro dissolution, Fourier-transform infrared spectroscopy, drug content estimation. The hydrophilic polymers, such as Avicel PH101, Alginic acid, and Aerosil200 were found to be effective in increasing the aqueous solubility and dissolution rate of Telmisartan in surface solid dispersions when compared to the pure drug.

Keywords: Telmisartan; Bioavailability; Aerosil; Solid Dispersion In Vitro Drug Release

Copyright: © 2018 A Supriya., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Member In



News and Events


  • Special Issue on Reviews
    Acta Scientific Journals has been started Special Issue on Reviews, researchers from world wide welcoming for submission of their reviews on any topic by on/ before August 30, 2019. Special Issue is going to be released on September 10, 2019
  • Submission Timeline for Regular Issue
    Last date for submission of articles is August 30, 2019.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US