A Supriya*, B Manasa, TN Shilpa, Rajesh Kaza, S Savithramma and D Prasadu
Department of Pharmaceutics, Jawaharlal Nehru Technological University Anantapur, India
*Corresponding Author: A Supriya, Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University Anantapur, India.
Received: December 30, 2017; Published: January 11, 2018
Citation: A Supriya., et al. “Dissolution Improvement of Telmisartan by Surface Solid Dispersion Method”. Acta Scientific Pharmaceutical Sciences 2.1 (2018).
The present study was aimed to improve the aqueous solubility and bioavailability of telmisartan by Surface solid dispersion technique. Surface Solid dispersions of Telmisartan were prepared by using hydrophilic polymers such as Avicel PH101, Alginic acid and Aerosil200. In different weight ratios by solvent evaporation method. The drug and the solid dispersions were characterized by saturation solubility studies, in-vitro dissolution, Fourier-transform infrared spectroscopy, drug content estimation. The hydrophilic polymers, such as Avicel PH101, Alginic acid, and Aerosil200 were found to be effective in increasing the aqueous solubility and dissolution rate of Telmisartan in surface solid dispersions when compared to the pure drug.
Keywords: Telmisartan; Bioavailability; Aerosil; Solid Dispersion In Vitro Drug Release
Copyright: © 2018 A Supriya., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.