Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 1

Molecular Spectroscopy Investigation on Pharmacodynamic Activity and Biological Property Analysis on Anti-Mycobacterial Drug; 4-Amino Salicylic Acid Using Computational Tools

R Aarthi1, S Ramalingam2* and S Periandy2

1Ph.D Scholar, Department of Physics, A.V.C. College, Mayiladuthurai, Tamilnadu, India
2Department of Physics, A.V.C. College, Mayiladuthurai, Tamilnadu, India
3Department of Physics, Kanchi Mamunivar Centre for PG studies, Puducherry, India

*Corresponding Author: S Ramalingam, Department of Physics, A.V.C. College, Mayiladuthurai, Tamilnadu, India.

Received: December 27, 2017; Published: January 11, 2018

Citation: S Ramalingam., et al. “Molecular Spectroscopy Investigation on Pharmacodynamic Activity and Biological Property Analysis on Anti-Mycobacterial Drug; 4-Amino Salicylic Acid Using Computational Tools”. Acta Scientific Pharmaceutical Sciences 2.1 (2018).

Abstract

 The Pharmacodynamic activity was keenly observed by recording FT-IR, FT-Raman, UV-Visible and NMR spectra of 4-Aminosalicylic acid. The observed absorption and scattering spectral sequence were analyzed to predict the role of compositional parts in the compound activity. The unknown physico-chemical properties were calculated and were correlated with the physical parameters. The drug activity of the compound was predicted by observing frontier molecular interaction profile. The electronic transitions among different energy levels of electronic structure were determined and hyperactive Polarizability causing the anti-micro bacterial activity was discussed. The exchange of chemical potential for creating drug potential by making transitions among non-bonding molecular orbitals has been examined. The QSAR properties were calculated and Lipinski’s rules for drug likeness were reported and discussed to recognize the biological activity of the molecule. The VCD spectrum in different range of IR region for determining enantiomer ability was replicated at stable conformer and the hiding of toxicity was predicted.

Keywords: 4-Aminosalicylic Acid; Physico-Chemical; Hyperactive Polarizability; QSAR Properties; Lipinski’s Rules; VCD Spectrum

Copyright: © 2018 S Ramalingam., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Member In



News and Events


  • Special Issue on Reviews
    Acta Scientific Journals has been started Special Issue on Reviews, researchers from world wide welcoming for submission of their reviews on any topic by on/ before August 30, 2019. Special Issue is going to be released on September 10, 2019
  • Submission Timeline for Regular Issue
    Last date for submission of articles is August 30, 2019.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US