Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 1

Estimation of Cefdinir in Bulk Drug Using Area Under Curve Method

Pritam S Jain1*, Vishal B Badgujar2, Gayatri B Patil1, Harshal P Chaudhari1 and Sanjay J Surana1

1R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India
2Academician and Researcher, UniKL RCMP, Perak, Malaysia

*Corresponding Author: Pritam S Jain, Associate Professor, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.

Received: December 18, 2017; Published: January 11, 2018

Citation: Pritam S Jain.,et al. “Estimation of Cefdinir in Bulk Drug Using Area Under Curve Method”. Acta Scientific Pharmaceutical Sciences 2.2 (2018).

Abstract

 A simple, rapid, accurate and economical UV-Spectrophotometric method has been developed for estimation of Cefdinir from bulk and pharmaceutical formulation. The λmax of Cefdinir in phosphate buffer pH7 was found to be 287 nm. The drug follows linearity in the concentration range 3 - 18 μg/ml with correlation coefficient value 0.999. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 98.00% - 102.00% was found in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 80%, 100% and 120%. The % recovery was found to be in the range 98.00% - 102.00%. The low values of % RSD are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D. value less than 2 indicate that the method was precise. Ruggedness of the proposed method was studied with the help of two analysts. The above method was a rapid and cost-effective quality-control tool for routine analysis of Cefdinir in bulk and in pharmaceutical dosage form.

Keywords: Cefdinir; UV-Spectrophotometry; Area Under Curve; Validation

Copyright: © 2018 Pritam S Jain.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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