M Padmaa Paarakh*
Department of Pharmacognosy, The Oxford College of Pharmacy, Bangalore, Karnataka, India
*Corresponding Author: M Padmaa Paarakh, Principal, Department of Pharmacognosy, The Oxford College of Pharmacy, Bangalore, Karnataka, India.
Received: December 20, 2017; Published: January 10, 2018
Citation: M Padmaa Paarakh. “In Silico Antidiabetic Activity of Limonene Isolated from Coriandrum sativum Linn Fruit”. Acta Scientific Pharmaceutical Sciences 2.1 (2018).
Background and Aim: Diabetes mellitus [DM] is a metabolic disorder characterized by disturbances in carbohydrate, protein and lipid metabolism and by complications like micro vascular (retinopathy, neuropathy and nephropathy) and macro vascular (heart attack, stroke and peripheral vascular disease) complications. Coriandrum sativum Linn has been claimed to possess antidiabetic properties in Traditional System of Medicine. This study aimed to evaluate molecular interaction of limonene in C. sativum and targeted protein related to Type 2 DM.
Material and Methods: Isolation of Limonene from the methanol extract of fruit of C. sativum was done by column chromatography. Evaluation of hypoglycemic activity through an in silico docking approach with molecular target such as glutamine: fructose- 6-phosphate amidotransferase was performed. Molecular docking study was performed with Autodock docking software.
Results: The docking studies of the ligand limonene with target protein showed that this is a good inhibitor, which docks well related to diabetes mellitus with -1.57768 kJ mol-1 Van der waal energy and -17.6701 kJ mol-1 as docking energy. Hence limonene can be considered for developing into a potent anti-diabetic drug.
Conclusion: Management of diabetes is challenge to the medical treatment. This leads to increasing demand for natural products with antidiabetic activity with fewer side effects. This work establishes C. sativum extract as a potential inhibitor for diabetes. Thus enabling a possibility of this plant extract as a new alternative to existing diabetic treatment.
Keywords: Coriandrum sativum; Diabetes Mellitus; Molecular Docking; In Silico; Limonene
Copyright: © 2018 M Padmaa Paarakh. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.