Acta Scientific Ophthalmology (ISSN: 2582-3191)

Short Communication Volume 4 Issue 9

Coenzyme Q10 and Neuroprotection

Italo Giuffre*

Ophthalmological Department, Medical School, Catholic University of Rome, Italy

*Corresponding Author: Italo Giuffre, Ophthalmological Department, Medical School, Catholic University of Rome, Italy.

Received: May 23, 2021; Published: August 16, 2021

  The retina is the most metabolically active tissue in the body, with the highest consumption of energy per unit area of tissue [1]. CoQ10 deficiency may cause retinopathy alone or as part of a syndrome. CoQ10 may play a role in the pathogenesis of retinal diseases. Age-related macular disease (AMD) is a major cause of visual impairment in elderly patients. They suffer from a loss of central vision. In AMD patients, CoQ10 plasma levels revealed lower than age-matched control subjects. These data suggest an association between oxidative stress and the pathogenesis of AMD.

References

  1. Manzar H., et al. “Cellular consequences of Coenzyme Q10 deficiency in neurodegeneration of the retina and brain”. International Journal of Molecular Sciences 21 (2020): 9299-9312.
  2. Lee D., et al. “Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury”. Apoptosis 19 (2014): 603-614.
  3. Feuer WJ., et al. “Gene therapy for Leber optic neuropathy: initial results”. Ophthalmology3 (2016): 158-170.
  4. Blasi MA., et al. “Does Coenzyme Q10 play a role in opposing oxidative stress in patients with age-related macular degeneration?” Ophthalmologica 215 (2001): 51-54.
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  6. Nucci C., et al. “New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system”. European Journal of Pharmacology 787 (2016): 119-126.
  7. Kernt M., et al. “Coenzyme Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX/BCL-2 ratio”. Acta Ophthalmologica 88 (2010): e78-e86.
  8. Tredici C., et al. “Efficacy of eye drops containing crosslinked hyaluronic acid and CoQ10 in restoring ocular health exposed to chlorinated water”. European Journal of Ophthalmology: SAGE Journals3 (2020): 430-438.
  9. Parisi V., et al. “Effects of coenzyme Q10 in conjunction with vitamin E on retinal-evoked and cortical-evoked responses in patients with open-angle glaucoma”. Journal of Glaucoma6 (2014): 391-404.

Citation

Citation: Italo Giuffre. “Coenzyme Q10 and Neuroprotection". Acta Scientific Ophthalmology 4.9 (2021): 29-30.

Copyright

Copyright: © 2021 Italo Giuffre. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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